One of the challenges of modern biology and medicine is to visualize biomolecules in their
natural environment, in real-time and in a non-invasive fashion, so as to gain insight into …

Drug-induced cardiotoxicity is a significant clinical issue, with many drugs in the market
being labeled with warnings on cardiovascular adverse effects. Treatments are often …

Inserting large DNA payloads (> 10 kb) into specific genomic sites of mammalian cells
remains challenging. Applications ranging from synthetic biology to evaluating the …

The composite material-like extracellular matrix (ECM) in the sinoatrial node (SAN) supports
the native pacemaking cardiomyocytes (PCMs). To test the roles of SAN ECM in the PCM …

Materials made of recombinant spider silk proteins are promising candidates for cardiac
tissue engineering, and their suitability has so far been investigated utilizing primary rat …

Optogenetics is a rapidly advancing technology combining photochemical, optical, and
synthetic biology to control cellular behavior. Together, sensitive light-responsive …

Genetically-encoded fluorescent sensors have been actively developed over the last few
decades and used in live imaging and drug screening. Real-time monitoring of drug action …

Oxidative stress plays an important role in the development of neurodegenerative diseases,
being either the initiator or part of a pathological cascade that leads to the neuron's death …

Brugada syndrome (BrS) is an inherited cardiac arrhythmia that predisposes to ventricular
fibrillation and sudden cardiac death. It originates from oligogenic alterations that affect …

The most widely used genome editing toolkit is CRISPR (clustered regularly interspaced
short palindromic repeats). It provides the possibility of replacing and modifying DNA and …