Integrons are versatile gene acquisition systems commonly found in bacterial genomes.
They are ancient elements that are a hot spot for genomic complexity, generating phenotypic …

The integron is a powerful system which, by capturing, stockpiling, and rearranging new
functions carried by gene encoding cassettes, confers upon bacteria a rapid adaptation …

The evolution of antibiotic resistance carries a fitness cost, expressed in terms of reduced
competitive ability in the absence of antibiotics. This cost plays a key role in the dynamics of …

Strain-to-strain variations in bacterial biofilm formation, metabolism, motility, virulence,
evolvability, DNA repair and resistance (to phage, antibiotics, or environmental stresses) …

Mobile integrons are widespread genetic platforms that allow bacteria to modulate the
expression of antibiotic resistance cassettes by shuffling their position from a common …

Integrons are genetic elements first described at the end of the 1980s. Although most
integrons were initially described in human clinical isolates, they have now been identified …

Background Integrons, especially the class 1 integrons, are major contributors to the
acquisition and dissemination of antibiotic resistance genes (ARGs). However …

The fitness effects of a mutation can depend, sometimes dramatically, on genetic
background; this phenomenon is often referred to as “epistasis.” Epistasis can have …

There is urgent need to develop novel treatment strategies to reduce antimicrobial
resistance. Collateral sensitivity (CS), where resistance to one antimicrobial increases …

Resistance integrons are bacterial genetic platforms that can capture and express antibiotic
resistance genes embedded within gene cassettes. The capture and shuffling of gene …