Redefining the cerebellar cortex as an assembly of non-uniform Purkinje cell microcircuits
NL Cerminara, EJ Lang, RV Sillitoe… - Nature Reviews …, 2015 - nature.com
The adult mammalian cerebellar cortex is generally assumed to have a uniform
cytoarchitecture. Differences in cerebellar function are thought to arise primarily through …
cytoarchitecture. Differences in cerebellar function are thought to arise primarily through …
The single dendritic branch as a fundamental functional unit in the nervous system
The conventional view of dendritic function is that dendrites collect synaptic input and deliver
it to the soma. This view has been challenged in recent years by new results demonstrating …
it to the soma. This view has been challenged in recent years by new results demonstrating …
Cerebellar dopamine D2 receptors regulate social behaviors
L Cutando, E Puighermanal, L Castell, P Tarot… - Nature …, 2022 - nature.com
The cerebellum, a primary brain structure involved in the control of sensorimotor tasks, also
contributes to higher cognitive functions including reward, emotion and social interaction …
contributes to higher cognitive functions including reward, emotion and social interaction …
The cerebellar dopaminergic system
P Flace, P Livrea, GA Basile, D Galletta… - Frontiers in systems …, 2021 - frontiersin.org
In the central nervous system (CNS), dopamine (DA) is involved in motor and cognitive
functions. Although the cerebellum is not been considered an elective dopaminergic region …
functions. Although the cerebellum is not been considered an elective dopaminergic region …
Purkinje cell-specific knockout of tyrosine hydroxylase impairs cognitive behaviors
Tyrosine hydroxylase (Th) expression has previously been reported in Purkinje cells (PCs)
of rodents and humans, but its role in the regulation of behavior is not understood …
of rodents and humans, but its role in the regulation of behavior is not understood …
Differential spatiotemporal development of Purkinje cell populations and cerebellum-dependent sensorimotor behaviors
GC Beekhof, C Osório, JJ White, S van Zoomeren… - Elife, 2021 - elifesciences.org
Distinct populations of Purkinje cells (PCs) with unique molecular and connectivity features
are at the core of the modular organization of the cerebellum. Previously, we showed that …
are at the core of the modular organization of the cerebellum. Previously, we showed that …
Systematic regional variations in Purkinje cell spiking patterns
J Xiao, NL Cerminara, Y Kotsurovskyy, H Aoki… - PloS one, 2014 - journals.plos.org
In contrast to the uniform anatomy of the cerebellar cortex, molecular and physiological
studies indicate that significant differences exist between cortical regions, suggesting that …
studies indicate that significant differences exist between cortical regions, suggesting that …
Functional outcomes of cerebellar malformations
JS Gill, RV Sillitoe - Frontiers in cellular neuroscience, 2019 - frontiersin.org
The cerebellum is well-established as a primary center for controlling sensorimotor
functions. However, recent experiments have demonstrated additional roles for the …
functions. However, recent experiments have demonstrated additional roles for the …
Stereotyped spatial patterns of functional synaptic connectivity in the cerebellar cortex
AM Valera, F Binda, SA Pawlowski, JL Dupont… - Elife, 2016 - elifesciences.org
Motor coordination is supported by an array of highly organized heterogeneous modules in
the cerebellum. How incoming sensorimotor information is channeled and communicated …
the cerebellum. How incoming sensorimotor information is channeled and communicated …
Lobule‐specific membrane excitability of cerebellar Purkinje cells
CH Kim, SH Oh, JH Lee, SO Chang… - The Journal of …, 2012 - Wiley Online Library
Non‐technical summary Cerebellar vermis consists of 10 lobules, and each lobule receives
different sensory information. Afferent inputs are integrated in cerebellar Purkinje cells (PCs) …
different sensory information. Afferent inputs are integrated in cerebellar Purkinje cells (PCs) …