Genetically encoded indicators of neuronal activity

MZ Lin, MJ Schnitzer - Nature neuroscience, 2016 - nature.com
Experimental efforts to understand how the brain represents, stores and processes
information require high-fidelity recordings of multiple different forms of neural activity within …

Imaging calcium in neurons

C Grienberger, A Konnerth - Neuron, 2012 - cell.com
Calcium ions generate versatile intracellular signals that control key functions in all types of
neurons. Imaging calcium in neurons is particularly important because calcium signals exert …

[HTML][HTML] Non-canonical odor coding in the mosquito

M Herre, OV Goldman, TC Lu, G Caballero-Vidal, Y Qi… - Cell, 2022 - cell.com
Aedes aegypti mosquitoes are a persistent human foe, transmitting arboviruses including
dengue when they feed on human blood. Mosquitoes are intensely attracted to body odor …

Mosquito brains encode unique features of human odour to drive host seeking

Z Zhao, JL Zung, A Hinze, AL Kriete, A Iqbal… - Nature, 2022 - nature.com
A globally invasive form of the mosquito Aedes aegypti specializes in biting humans, making
it an efficient disease vector. Host-seeking female mosquitoes strongly prefer human odour …

Cryo-EM structure of the insect olfactory receptor Orco

JA Butterwick, J Del Mármol, KH Kim, MA Kahlson… - Nature, 2018 - nature.com
The olfactory system must recognize and discriminate amongst an enormous variety of
chemicals in the environment. To contend with such diversity, insects have evolved a family …

A genetically encoded fluorescent acetylcholine indicator for in vitro and in vivo studies

M Jing, P Zhang, G Wang, J Feng, L Mesik… - Nature …, 2018 - nature.com
The neurotransmitter acetylcholine (ACh) regulates a diverse array of physiological
processes throughout the body. Despite its importance, cholinergic transmission in the …

A nutrient-specific gut hormone arbitrates between courtship and feeding

HH Lin, MC Kuang, I Hossain, Y Xuan, L Beebe… - Nature, 2022 - nature.com
Animals must set behavioural priority in a context-dependent manner and switch from one
behaviour to another at the appropriate moment,–. Here we probe the molecular and …

Imaging neural activity in worms, flies and mice with improved GCaMP calcium indicators

L Tian, SA Hires, T Mao, D Huber, ME Chiappe… - Nature …, 2009 - nature.com
Genetically encoded calcium indicators (GECIs) can be used to image activity in defined
neuronal populations. However, current GECIs produce inferior signals compared to …

Deep tissue two-photon microscopy

F Helmchen, W Denk - Nature methods, 2005 - nature.com
With few exceptions biological tissues strongly scatter light, making high-resolution deep
imaging impossible for traditional—including confocal—fluorescence microscopy. Nonlinear …

Random convergence of olfactory inputs in the Drosophila mushroom body

SJC Caron, V Ruta, LF Abbott, R Axel - Nature, 2013 - nature.com
The mushroom body in the fruitfly Drosophila melanogaster is an associative brain centre
that translates odour representations into learned behavioural responses. Kenyon cells, the …