Microtubules play a crucial role in multiple cellular functions including mitosis, cell signaling,
and organelle trafficking, which makes the microtubule an important target for cancer …

The topoisomerase enzymes play an important role in DNA metabolism, and searching for
enzyme inhibitors is an important target in the search for new anticancer drugs. Discovery of …

The DNA topoisomerase enzymes are essential to cell function and are found ubiquitously
in all domains of life. The various topoisomerase enzymes perform a wide range of functions …

Abstract Topoisomerase IB (Top1), a subcategory of DNA topoisomerase enzymes is
expressed much higher in several tumor cells. Therefore, modulating the activity of Top1 in …

Scaffold diversity is a crucial feature of compound collections that has a huge impact on their
success in biological screenings. The synthesis of highly complex and diverse scaffolds …

A metal-free system has been discovered for the efficient α-oxygenation of tertiary amines to
the corresponding amides using oxygen as an oxidant. This visible-light-mediated …

Ethnopharmacological relevance Evodia rutaecarpa, a well-known herb medicine in China,
is extensively applied in traditional Chinese medicine (TCM). The plant has the effects of …

Abstract 1, 2, 3, 4-Tetrahydro-β-carboline (THβC) scaffold is widespread in many natural
products (NPs) and synthetic compounds which show a variety of pharmacological activities …

DNA topoisomerase II (topo II) is an important enzyme involved in DNA replication,
recombination, and repair. Despite the popular applications of topo II inhibitors in cancer …

Exploring multi-targeting chemotherapeutants with advantages over single-targeting agents
and drug combinations is of great significance in drug discovery. Herein, we employed …