Mechanisms underlying mechanical overload-induced skeletal muscle hypertrophy have
been extensively researched since the landmark report by Morpurgo (1897) of “work …

One of the most striking adaptations to exercise is the skeletal muscle hypertrophy that
occurs in response to resistance exercise. A large body of work shows that a mammalian …

Satellite cells support adult skeletal muscle fiber adaptations to loading in numerous ways.
The fusion of satellite cells, driven by cell‐autonomous and/or extrinsic factors, contributes …

Skeletal muscle plays a critical role in physical function and metabolic health. Muscle is a
highly adaptable tissue that responds to resistance exercise (RE; loading) by …

Skeletal muscle plays a pivotal role in the maintenance of physical and metabolic health
and, critically, mobility. Accordingly, strategies focused on increasing the quality and quantity …

Multinuclear muscle fibers are the most voluminous cells in skeletal muscle and the primary
drivers of growth in response to loading. Outside the muscle fiber, however, is a diversity of …

Numerous reports suggest there are low and high skeletal muscle hypertrophic responders
following weeks to months of structured resistance exercise training (referred to as low and …

Satellite cell-mediated myonuclear accretion is thought to be required for skeletal muscle
fiber hypertrophy, and even drive hypertrophy by preceding growth. Recent studies in …

The functional role of Pax7-expressing satellite cells (SCs) in postnatal skeletal muscle
development beyond weaning remains obscure. Therefore, the relevance of SCs during …

For centuries, regular exercise has been acknowledged as a potent stimulus to promote,
maintain, and restore healthy functioning of nearly every physiological system of the human …