Maternal immune activation and neuroinflammation in human neurodevelopmental disorders

VX Han, S Patel, HF Jones, RC Dale - Nature Reviews Neurology, 2021 - nature.com
Maternal health during pregnancy plays a major role in shaping health and disease risks in
the offspring. The maternal immune activation hypothesis proposes that inflammatory …

COVID-19 in pregnancy: implications for fetal brain development

LL Shook, EL Sullivan, JO Lo, RH Perlis… - Trends in molecular …, 2022 - cell.com
The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection
during pregnancy on the developing fetal brain is poorly understood. Other antenatal …

[HTML][HTML] Maternal nutrition and neurodevelopment: a scoping review

MC Cortés-Albornoz, DP García-Guáqueta… - Nutrients, 2021 - mdpi.com
In this scoping review, we examined the association between maternal nutrition during
pregnancy and neurodevelopment in offspring. We searched the Pubmed and …

Innate immunity at the crossroads of healthy brain maturation and neurodevelopmental disorders

KE Zengeler, JR Lukens - Nature Reviews Immunology, 2021 - nature.com
The immune and nervous systems have unique developmental trajectories that individually
build intricate networks of cells with highly specialized functions. These two systems have …

[HTML][HTML] Interferons and proinflammatory cytokines in pregnancy and fetal development

LJ Yockey, A Iwasaki - Immunity, 2018 - cell.com
Successful pregnancy requires carefully-coordinated communications between the mother
and fetus. Immune cells and cytokine signaling pathways participate as mediators of these …

[HTML][HTML] Transcriptional and epigenetic decoding of the microglial aging process

X Li, Y Li, Y Jin, Y Zhang, J Wu, Z Xu, Y Huang, L Cai… - Nature Aging, 2023 - nature.com
As important immune cells, microglia undergo a series of alterations during aging that
increase the susceptibility to brain dysfunctions. However, the longitudinal characteristics of …

[HTML][HTML] Neuroinflammation and oxidative stress in the pathogenesis of autism spectrum disorder

N Usui, H Kobayashi, S Shimada - International Journal of Molecular …, 2023 - mdpi.com
Autism spectrum disorder (ASD) is a neurodevelopmental disorder (NDD) characterized by
impairments in social communication, repetitive behaviors, restricted interests, and …

Microglia and early brain development: An intimate journey

MS Thion, F Ginhoux, S Garel - Science, 2018 - science.org
Cross-talk between the nervous and immune systems has been well described in the
context of adult physiology and disease. Recent advances in our understanding of immune …

Comprehensive analysis of COVID-19 during pregnancy

KM Moore, MS Suthar - Biochemical and biophysical research …, 2021 - Elsevier
The COVID-19 pandemic resulting from the emergence of the coronavirus SARS-CoV-2
remains a major global health concern. Pregnant individuals are more likely to develop …

[HTML][HTML] Prenatal interleukin 6 elevation increases glutamatergic synapse density and disrupts hippocampal connectivity in offspring

F Mirabella, G Desiato, S Mancinelli, G Fossati… - Immunity, 2021 - cell.com
Early prenatal inflammatory conditions are thought to be a risk factor for different
neurodevelopmental disorders. Maternal interleukin-6 (IL-6) elevation during pregnancy …