Hirschsprung disease (HSCR, aganglionic megacolon) represents the main genetic cause
of functional intestinal obstruction with an incidence of 1/5000 live births. This …

The neural crest (NC) yields pluripotent cells endowed with migratory properties. They give
rise to neurons, glia, melanocytes and endocrine cells, and to diversemesenchymal' …

To improve our ability to identify hematopoietic stem cells (HSCs) and their localization in
vivo, we compared the gene expression profiles of highly purified HSCs and non-self …

Human breast tumors contain a breast cancer stem cell (BCSC) population with properties
reminiscent of normal stem cells. We found 37 microRNAs that were differentially expressed …

A fundamental question in cancer biology is whether cells with tumorigenic potential are
common or rare within human cancers. Studies on diverse cancers, including melanoma …

The isolation of human induced pluripotent stem cells (iPSCs),, offers a new strategy for
modelling human disease. Recent studies have reported the derivation and differentiation of …

Vertebrate neural crest development depends on pluripotent, migratory precursor cells.
Although avian and murine neural crest stem (NCS) cells have been identified, the isolation …

The variety of diseases caused by mutations in RET receptor tyrosine kinase provides a
classic example of phenotypic heterogeneity. Gain-of-function mutations of RET are …

Proteins from the Polycomb group (PcG) are epigenetic chromatin modifiers involved in
cancer development and also in the maintenance of embryonic and adult stem cells. The …

For both vertebrate developmental and evolutionary biologists, and also for clinicians, the
neural crest (NC) is a fundamental cell population. An understanding of Sox10 function in …