Abstract Pyrazolo [1, 5-a] pyrimidine scaffold is one of the privileged hetrocycles in drug
discovery. Its application as a buliding block for developing drug-like candidates has …

Chalcones belong to the flavonoid family which constitutes one of the major classes of
naturally occurring oxygen heterocyclic compounds. The α, β-unsaturated carbonyl system …

Three different series of ethylidenehydrazonothiazoles 5a-c, 6a-c, ethylidenehydrazono-1, 3-
thiazines 9a-i and ethylidenehydrazonothiazolidine 12 have been prepared via reactions of …

Acute myeloid leukemia (AML) stands as one of the most aggressive type of human cancer
that can develop rapidly and thus requires immediate management. In the current study, the …

Scaffolds hybridization is a well-known drug design strategy for antitumor agents. Herein,
series of novel indolyl-pyrimidine hybrids were synthesized and evaluated in vitro and in …

ABSTRACT A novel series of pyrazolo [1, 5-a] pyrimidines 14a–j and pyrazolo [1, 5-a]
quinazolines 18a, b were synthesized via condensation of 5-amino-1 H-pyrazoles 10a, b …

Background Pyrazolopyrimidine heterocycle and its isosteres represent the main scaffold for
many pharmacologically active drugs including anti-inflammatory agents. The COX-2 …

A general and expeditious approach for the copper mediated synthesis of multi‐
functionalized dihydropyrazoles from N‐sulfonylhydrazones and sulfoxonium ylides has …

Abstract Two new series of 1, 5-diaryl pyrazoles (5a, 5b, 7a, 7b and 10) and 1, 5-diaryl
pyrazoline (12a and 12b) were prepared as both Cyclooxygenase-2 and 15-lipoxygenase …

Abstract The reaction of 5-amino-3-(4-methoxyphenylamino)-$ N $-aryl-1$ H $-pyrazole-4-
carboxamides\textbf {1a}--\textbf {c} with ethyl acetoacetate\textbf {2} and 2-(4 …