Tumor microenvironments are the result of cellular alterations in cancer that support
unrestricted growth and proliferation and result in further modifications in cell behavior …

“What is the O2 concentration in a normoxic cell culture incubator?” This and other
frequently asked questions in hypoxia research will be answered in this review. Our …

In the nervous system, neural stem cells (NSCs) are necessary for the generation of new
neurons and for cognitive function. Here we show that FoxO3, a member of a transcription …

Changes in oxygen concentrations affect many of the innate characteristics of stem and
progenitor cells. Human mesenchymal stem cells (hMSCs) were maintained under hypoxic …

The adult mammalian brain contains a population of neural stem cells that can give rise to
neurons, astrocytes, and oligodendrocytes and are thought to be involved in certain forms of …

General anesthetics are commonly used in major surgery. To achieve the depth of
anesthesia for surgery, patients are being subjected to a variety of general anesthetics …

Low oxygen tension is thought to be an integral component of the human mesenchymal
stem cell (hMSC) native bone marrow microenvironment. HMSC were cultured under …

Abstract Human CD133 (human prominin-1), a five transmembrane domain glycoprotein,
was originally identified as a cell surface antigen present on CD34+ hematopoietic stem …

Over the course of pregnancy, the human uterus undergoes a 500-to 1,000-fold increase in
volume and a 24-fold increase in weight. The uterine smooth muscle layer or myometrium is …

Obesity is an important public health problem worldwide and is a major risk factor for a
number of chronic diseases such as type II diabetes, adverse cardiovascular events and …