Radiotherapy combined with immunotherapy: the dawn of cancer treatment

Z Zhang, X Liu, D Chen, J Yu - Signal Transduction and Targeted …, 2022 - nature.com
Radiotherapy (RT) is delivered for purposes of local control, but can also exert systemic
effect on remote and non-irradiated tumor deposits, which is called abscopal effect. The view …

Radiotherapy as a means to increase the efficacy of T-cell therapy in solid tumors

PA Laurent, D Morel, L Meziani, S Depil… - …, 2023 - Taylor & Francis
Chimeric antigen receptor (CAR)-T cells have demonstrated significant improvements in the
treatment of refractory B-cell malignancies that previously showed limited survival. In …

High-dose irradiation in combination with non-ablative low-dose radiation to treat metastatic disease after progression on immunotherapy: Results of a phase II trial

RR Patel, K He, HB Barsoumian, JY Chang… - Radiotherapy and …, 2021 - Elsevier
Aim To report early findings from a phase II trial of high-dose radiotherapy (HD-RT) with or
without low-dose RT (LD-RT) for metastatic cancer. Methods Eligible patients had metastatic …

[HTML][HTML] Imaging approaches and radiomics: toward a new era of ultraprecision radioimmunotherapy?

R Sun, T Henry, A Laville, A Carré… - … for Immunotherapy of …, 2022 - ncbi.nlm.nih.gov
Strong rationale and a growing number of preclinical and clinical studies support combining
radiotherapy and immunotherapy to improve patient outcomes. However, several critical …

[HTML][HTML] Novel unconventional radiotherapy techniques: Current status and future perspectives–Report from the 2nd international radiation oncology online seminar

S Tubin, MC Vozenin, Y Prezado, M Durante… - Clinical and …, 2023 - Elsevier
Novel unconventional radiotherapy techniques: Current status and future perspectives –
Report from the 2nd international radiation oncology online seminar - ScienceDirect Skip to …

Therapy-induced modulation of the tumor microenvironment: new opportunities for cancer therapies

S Benavente, A Sánchez-García, S Naches… - Frontiers in …, 2020 - frontiersin.org
Advances in immunotherapy have achieved remarkable clinical outcomes in tumors with low
curability, but their effects are limited, and increasing evidence has implicated tumoral and …

Definitive local consolidative therapy for oligometastatic solid tumors: results from the lead-in phase of the randomized basket trial EXTEND

AD Sherry, TK Bathala, S Liu, BM Fellman… - International Journal of …, 2022 - Elsevier
Purpose The benefit of local consolidative therapy (LCT) for oligometastasis across
histologies remains uncertain. EXTernal beam radiation to Eliminate Nominal metastatic …

Optimize Local Therapy for Oligometastatic and Oligoprogressive Non–Small Cell Lung Cancer to Enhance Survival

JY Chang, V Verma - Journal of the National Comprehensive Cancer …, 2022 - jnccn.org
Metastatic non–small cell lung cancer (NSCLC) is highly heterogeneous, and there are
patients with limited areas of metastases (oligometastases) or progression …

Optimized CAR-T therapy based on spatiotemporal changes and chemotactic mechanisms of MDSCs induced by hypofractionated radiotherapy

B Zhang, M Hu, Q Ma, K Li, X Li, X He, P Shu, Y Chen… - Molecular Therapy, 2023 - cell.com
Poor intratumoral infiltration is the major challenge for chimeric antigen receptor (CAR)-T
cell therapy in solid tumors. Hypofractionated radiotherapy (HFRT) has been reported to …

Local consolidative therapy versus systemic therapy alone for metastatic non-small cell lung cancer: a systematic review and meta-analysis

Y Wu, V Verma, F Liang, Q Lin, Z Zhou, Z Wang… - International Journal of …, 2022 - Elsevier
Purpose The role of local consolidative therapy (LCT) for metastatic cancers most likely
varies by the particular cancer type. We therefore performed a systematic review with a …