Eukaryotic cells have been confronted throughout their evolution with potentially lethal
plasma membrane injuries, including those caused by osmotic stress, by infection from …

Skeletal muscle continuously adapts to changes in its mechanical environment through
modifications in gene expression and protein stability that affect its physiological function …

Calpains are cysteine proteases expressed in skeletal muscle fibers and other cells.
Although calpain was first reported to act as a kinase activating factor in skeletal muscle, the …

X-ROS signaling is a novel redox signaling pathway that links mechanical stress to changes
in [Ca2+] i. This pathway is activated rapidly and locally within a muscle cell under …

Dysferlinopathies, most commonly limb girdle muscular dystrophy 2B and Miyoshi
myopathy, are degenerative myopathies caused by mutations in the DYSF gene encoding …

Myotonic dystrophy type 1 (DM1) is caused by an unstable CTG repeat expansion in the 3′
UTR of the DM protein kinase (DMPK) gene. DMPK transcripts carrying CUG expansions …

Muscular dystrophies are genetically diverse but share common phenotypic features of
muscle weakness, degeneration, and progressive decline in muscle function. Previous work …

Repair of plasma membrane tears is an important normal physiological process that enables
the cells to survive a variety of physiological and pathological membrane lesions. Dysferlin …

Mutations in the dysferlin gene underlie a group of autosomal recessive muscle-wasting
disorders denoted as dysferlinopathies. Dysferlin has been shown to play roles in muscle …

The class of muscular dystrophies linked to the genetic ablation or mutation of dysferlin,
including Limb Girdle Muscular Dystrophy 2B (LGMD2B) and Miyoshi Myopathy (MM), are …