In eukaryotes, poly (A) tails are present on almost every mRNA. Early experiments led to the
hypothesis that poly (A) tails and the cytoplasmic polyadenylate-binding protein (PABPC) …

The advent of ribosome profiling and other tools to probe mRNA translation has revealed
that codon bias—the uneven use of synonymous codons in the transcriptome—serves as a …

The biological interpretation of gene lists with interesting shared properties, such as up-or
down-regulation in a particular experiment, is typically accomplished using gene ontology …

Following fertilization, the two specified gametes must unite to create an entirely new
organism. The genome is initially transcriptionally quiescent, allowing the zygote to be …

The development of animal embryos is initially directed by maternal gene products. Then,
during the maternal-to-zygotic transition (MZT), developmental control is handed to the …

Stem cells are characterized by their ability to self-renew and differentiate into many different
cell types. Research has focused primarily on how these processes are regulated at a …

The discovery of the genetic code and tRNAs as decoders of the code transformed life
science. However, after establishing the role of tRNAs in protein synthesis, the field moved …

The maternal-to-zygotic transition (MZT) is a conserved and fundamental process during
which the maternal environment is converted to an environment of embryonic-driven …

Codon usage bias, the preference for certain synonymous codons, is found in all genomes.
Although synonymous mutations were previously thought to be silent, a large body of …

Codon usage biases are found in all eukaryotic and prokaryotic genomes, and preferred
codons are more frequently used in highly expressed genes. The effects of codon usage on …