[HTML][HTML] Enzyme therapy: current challenges and future perspectives
M de la Fuente, L Lombardero… - International Journal of …, 2021 - mdpi.com
In recent years, enzymes have risen as promising therapeutic tools for different pathologies,
from metabolic deficiencies, such as fibrosis conditions, ocular pathologies or joint …
from metabolic deficiencies, such as fibrosis conditions, ocular pathologies or joint …
Development of a highly efficient long-acting cocaine hydrolase entity to accelerate cocaine metabolism
It is particularly challenging to develop a truly effective pharmacotherapy for cocaine use
disorder (CUD) treatment. Accelerating cocaine metabolism via hydrolysis at cocaine …
disorder (CUD) treatment. Accelerating cocaine metabolism via hydrolysis at cocaine …
[HTML][HTML] Catalytic activities of a highly efficient cocaine hydrolase for hydrolysis of biologically active cocaine metabolites norcocaine and benzoylecgonine
Cocaine is a widely abused, hepatotoxic drug without an FDA-approved pharmacotherapy
specific for cocaine addiction or overdose. It is recognized as a promising therapeutic …
specific for cocaine addiction or overdose. It is recognized as a promising therapeutic …
Cocaine hydrolase blocks cocaine‐induced dopamine transporter trafficking to the plasma membrane
Cocaine blocks dopamine uptake via dopamine transporter (DAT) on plasma membrane of
neuron cells and, as a result, produces the high and induces DAT trafficking to plasma …
neuron cells and, as a result, produces the high and induces DAT trafficking to plasma …
In vivo characterization of toxicity of norcocaethylene and norcocaine identified as the most toxic cocaine metabolites in male mice
Background Majority of cocaine users also consume alcohol, and concurrent use of cocaine
and alcohol produces cocaethylene, norcocaine, norcocaethylene, and other non-toxic …
and alcohol produces cocaethylene, norcocaine, norcocaethylene, and other non-toxic …
Clinical potential of a rationally engineered enzyme for treatment of cocaine dependence: Long-lasting blocking of the psychostimulant, discriminative stimulus, and …
It is a grand challenge to develop a truly effective treatment of substance use disorder
(SUD), particularly for cocaine and other drugs without an FDA-approved treatment …
(SUD), particularly for cocaine and other drugs without an FDA-approved treatment …
[HTML][HTML] In vitro and in vivo stability of a highly efficient long-acting cocaine hydrolase
It is recognized as a promising therapeutic strategy for cocaine use disorder to develop an
efficient enzyme which can rapidly convert cocaine to physiologically inactive metabolites …
efficient enzyme which can rapidly convert cocaine to physiologically inactive metabolites …
Kinetic characterization of an efficient cocaine hydrolase against toxic metabolites of cocaine
In the presence of alcohol, cocaine metabolism produces a number of metabolites, including
three toxic ones (cocaethylene, norcocaine, and norcocaethylene) which are all more toxic …
three toxic ones (cocaethylene, norcocaine, and norcocaethylene) which are all more toxic …
Catalytic reaction mechanism for drug metabolism in human carboxylesterase-1: cocaine hydrolysis pathway
Carboxylesterase-1 (CE-1) is a crucial enzyme responsible for metabolism/activation/
inactivation of xenobiotics (therapeutic agents, prodrugs, abused drugs, and …
inactivation of xenobiotics (therapeutic agents, prodrugs, abused drugs, and …
Structure-based design and discovery of a long-acting cocaine hydrolase mutant with improved binding affinity to neonatal Fc receptor for treatment of cocaine abuse
Despite decades of efforts to develop a pharmacotherapy for cocaine abuse treatment, there
is still no FDA-approved treatment of diseases associated with this commonly abused drug …
is still no FDA-approved treatment of diseases associated with this commonly abused drug …