Limitations and opportunities of technologies for the analysis of cell-free DNA in cancer diagnostics

P Song, LR Wu, YH Yan, JX Zhang, T Chu… - Nature biomedical …, 2022 - nature.com
Cell-free DNA (cfDNA) in the circulating blood plasma of patients with cancer contains
tumour-derived DNA sequences that can serve as biomarkers for guiding therapy, for the …

ctDNA applications and integration in colorectal cancer: an NCI Colon and Rectal–Anal Task Forces whitepaper

A Dasari, VK Morris, CJ Allegra, C Atreya… - Nature reviews Clinical …, 2020 - nature.com
An increasing number of studies are describing potential uses of circulating tumour DNA
(ctDNA) in the care of patients with colorectal cancer. Owing to this rapidly developing area …

Minimal residual disease detection using a plasma-only circulating tumor DNA assay in patients with colorectal cancer

AR Parikh, EE Van Seventer, G Siravegna… - Clinical Cancer …, 2021 - AACR
Purpose: Detection of persistent circulating tumor DNA (ctDNA) after curative-intent surgery
can identify patients with minimal residual disease (MRD) who will ultimately recur. Most …

Integrating circulating-free DNA (cfDNA) analysis into clinical practice: opportunities and challenges

M Garcia-Pardo, M Makarem, JJN Li, D Kelly… - British Journal of …, 2022 - nature.com
In the current era of precision medicine, the identification of genomic alterations has
revolutionised the management of patients with solid tumours. Recent advances in the …

Deep sequencing of circulating tumor DNA detects molecular residual disease and predicts recurrence in gastric cancer

J Yang, Y Gong, VK Lam, Y Shi, Y Guan, Y Zhang… - Cell death & …, 2020 - nature.com
Identifying locoregional gastric cancer patients who are at high risk for relapse after
resection could facilitate early intervention. By detecting molecular residual disease (MRD) …

[HTML][HTML] Early stage colon cancer: Current treatment standards, evolving paradigms, and future directions

S Chakrabarti, CY Peterson, D Sriram… - World journal of …, 2020 - ncbi.nlm.nih.gov
Colon cancer continues to be one of the leading causes of mortality and morbidity
throughout the world despite the availability of reliable screening tools and effective …

[HTML][HTML] Detection of minimal residual disease using ctDNA in lung cancer: current evidence and future directions

YK Chae, MS Oh - Journal of thoracic oncology, 2019 - Elsevier
Advances in DNA sequencing methods have significantly expanded the potential clinical
applications of analyzing circulating tumor DNA (ctDNA). This genetic information can …

[HTML][HTML] Diagnostic value of liquid biopsy in the era of precision medicine: 10 years of clinical evidence in cancer

V Caputo, F Ciardiello, CM Della Corte… - … of targeted anti-tumor …, 2023 - ncbi.nlm.nih.gov
Liquid biopsy is a diagnostic repeatable test, which in last years has emerged as a powerful
tool for profiling cancer genomes in real-time with minimal invasiveness and tailoring …

The promise of circulating tumor DNA (ctDNA) in the management of early-stage colon cancer: a critical review

S Chakrabarti, H Xie, R Urrutia, A Mahipal - Cancers, 2020 - mdpi.com
Simple Summary Currently, the treatment for localized colon cancer consists of surgery and,
if the presence of residual cancer cells is suspected, chemotherapy following the surgery …

Molecular residual disease and adjuvant trial design in solid tumors

M Coakley, I Garcia-Murillas, NC Turner - Clinical Cancer Research, 2019 - AACR
Advances in diagnosis and treatment have resulted in a high rate of survival for many
patients with early-stage cancers. However, identifying who is at ongoing risk of relapse …