Accumulating evidence indicates that gene order in eukaryotic genomes is not completely
random and that genes with similar expression levels tend to be clustered within the same …

Mammalian genomes are pervasively transcribed, to produce thousands of long non-coding
RNAs (lncRNAs),. A few of these lncRNAs have been shown to recruit regulatory complexes …

Abstract Background The newly assembled Bos taurus genome sequence enables the
linkage of bovine milk and lactation data with other mammalian genomes. Results Using …

How cells regulate protein levels is a central question of biology. Over the past decades,
molecular biology research has provided profound insights into the mechanisms and the …

Atherosclerosis is a chronic inflammatory disease that is driven, in part, by activation of
vascular endothelial cells (ECs). In response to inflammatory stimuli, the nuclear factor …

When considering the evolution of a gene's expression profile, we commonly assume that
this is unaffected by its genomic neighborhood. This is, however, in contrast to what we …

Abstract The Transforming Growth Factor-β (TGFβ) signaling pathway controls transcription
by regulating enhancer activity. How TGFβ-regulated enhancers are selected and what …

Paralog genes arise from gene duplication events during evolution, which often lead to
similar proteins that cooperate in common pathways and in protein complexes …

Genes are not randomly distributed in the genome. In humans, 10% of protein‐coding genes
are transcribed from bidirectional promoters and many more are organised in larger clusters …

Dysregulation of transcriptional pathways is observed in multiple forms of
neurodevelopmental disorders (NDDs), such as intellectual disability (ID), epilepsy and …