Synthetic and natural compounds that interact with human cytochrome P450 1A2 and implications in drug development
Human cytochrome P450 1A2 (CYP1A2) is one of the major CYPs in the liver (&sim13%)
and metabolizes about 20% of clinically used drugs. CYP1A2 is a 515-residue protein with a …
and metabolizes about 20% of clinically used drugs. CYP1A2 is a 515-residue protein with a …
Role of GABAA receptors in the physiology and pharmacology of sleep
R Winsky‐Sommerer - European Journal of Neuroscience, 2009 - Wiley Online Library
Most sedative‐hypnotics used in insomnia treatment target the γ‐aminobutyric acid (GABA)
A receptors. A vast repertoire of GABAA receptor subtypes has been identified and displays …
A receptors. A vast repertoire of GABAA receptor subtypes has been identified and displays …
A Straightforward Approach to Fluorinated Pyrimido[1,2-b]indazole Derivatives via Metal/Additive-Free Annulation with Enaminones, 3-Aminoindazoles, and …
Z Xu, X Geng, Y Cai, L Wang - The Journal of Organic Chemistry, 2022 - ACS Publications
A novel and efficient three-component reaction with two C–N bonds and one C–F bond
formation has been reported, which provides a straightforward route to a variety of …
formation has been reported, which provides a straightforward route to a variety of …
Appraisal of the role of In silico Methods in Pyrazole based drug design
Pyrazole and its derivatives are a pharmacologically and significantly active scaffolds that
have innumerable physiological and pharmacological activities. They can be very good …
have innumerable physiological and pharmacological activities. They can be very good …
Synthesis of 4-(pyrazol-1-yl) pyrimidines from 4-hydrazinopyrimidines and investigation of their structure and some chemical properties
GG Danagulyan, MR Arakelyan, NA Aksenov… - Journal of Molecular …, 2024 - Elsevier
Abstract By reacting 2-benzyl-4-hydrazinopyrimidines with ethoxymethylidene derivatives of
β-dicarbonyl compounds, the corresponding substituted 4-(1H-pyrazol-1-yl) pyrimidines …
β-dicarbonyl compounds, the corresponding substituted 4-(1H-pyrazol-1-yl) pyrimidines …
Emerging drugs for insomnia: new frontiers for old and novel targets
SS Sullivan, C Guilleminault - Expert opinion on emerging drugs, 2009 - Taylor & Francis
Background: Insomnia is the most prevalent sleep disorder, with up to 50% of the US adult
population reporting symptoms of insomnia on a weekly basis and∼ 12% with insomnia …
population reporting symptoms of insomnia on a weekly basis and∼ 12% with insomnia …
New approaches for the treatment of sleep disorders
NA DeMartinis, J Kamath, A Winokur - Advances in pharmacology, 2009 - Elsevier
Epidemiological studies have established that sleep disorders are common and often
untreated. Besides having a negative impact on overall health, these conditions can …
untreated. Besides having a negative impact on overall health, these conditions can …
Development of Subtype-Selective GABAA Receptor Compounds for the Treatment of Anxiety, Sleep Disorders and Epilepsy
JR Atack - GABA and sleep: Molecular, functional and clinical …, 2010 - Springer
There is little doubt regarding the therapeutic possibilities of modulation of GABA A receptor
function as exemplified by the clinical utility of benzodiazepines for half a century. The …
function as exemplified by the clinical utility of benzodiazepines for half a century. The …
[图书][B] Effects of Psychoactive Chemicals on Commercial Driver Health and Performance: Stimulants, Hypnotics, Nutritional, and Other Supplements
GP Krueger, HM Leaman, G Bergoffen, DC Murray… - 2011 - books.google.com
TRB's Commercial Truck and Bus Safety Synthesis Program (CTBSSP) Synthesis 19: Effects
of Psychoactive Chemicals on Commercial Driver Health and Performance: Stimulants …
of Psychoactive Chemicals on Commercial Driver Health and Performance: Stimulants …
[HTML][HTML] Anti-aggregation effect on platelets of Indiplon a hypnotic sedative non-benzodiazepine drug
Cardiovascular diseases are one of the main public health problems, and many of them,
their pathophysiology involves alterations in platelet activity. Platelet activation is an …
their pathophysiology involves alterations in platelet activity. Platelet activation is an …