To understand brain function, it is essential that we discover how cellular signaling specifies
normal and pathological brain function. In this regard, chemogenetic technologies represent …

Health nudge interventions to steer people into healthier lifestyles are increasingly applied
by governments worldwide, and it is natural to look to such approaches to improve health by …

The persistence of negative affect in pain leads to co-morbid symptoms such as anhedonia
and depression—major health issues in the United States. The neuronal circuitry and …

Abstract “Food addiction” has become a focus of interest for researchers attempting to
explain certain processes and/or behaviors that may contribute to the development of …

Clozapine N-oxide (CNO) is a ligand for a powerful chemogenetic system that can
selectively inhibit or activate neurons; the so-called Designer Receptors Exclusively …

Technological advances over the last decade are changing the face of behavioral
neuroscience research. Here we review recent work on the use of one such transformative …

Inputs from the ventral hippocampus (vHIP) to the medial prefrontal cortex (mPFC) are
implicated in several neuropsychiatric disorders. Here, we show that the vHIP-mPFC …

In order to thrive, animals must be able to recognize aversive and appetitive stimuli within
the environment and subsequently initiate appropriate behavioral responses. This …

The past decade has produced an explosion in the number and variety of genetic tools
available to neuroscientists, resulting in an unprecedented ability to precisely manipulate …

The last decade has seen major advances in neuroscience tools allowing us to selectively
modulate cellular pathways in freely moving animals. Chemogenetic approaches such as …