Neuropathic pain can develop after nerve injury, when deleterious changes occur in injured
neurons and along nociceptive and descending modulatory pathways in the central nervous …

There is tremendous interpatient variability in the response to analgesic therapy (even for
efficacious treatments), which can be the source of great frustration in clinical practice. This …

The past few decades have witnessed a huge leap forward in our understanding of the
mechanistic underpinnings of pain, in normal states where it helps protect from injury, and …

Nociceptor inputs can trigger a prolonged but reversible increase in the excitability and
synaptic efficacy of neurons in central nociceptive pathways, the phenomenon of central …

Neuropathic pain develops as a result of lesions or disease affecting the somatosensory
nervous system either in the periphery or centrally. Examples of neuropathic pain include …

After nerve injury maladaptive changes can occur in injured sensory neurons and along the
entire nociceptive pathway within the CNS, which may lead to spontaneous pain or pain …

The measurement of pain in animals is surprisingly complex, and remains a critical issue in
veterinary care and biomedical research. Based on the known utility of pain measurement …

We recently demonstrated the utility of quantifying spontaneous pain in mice via the blinded
coding of facial expressions. As the majority of preclinical pain research is in fact performed …

The Neuropathic Pain Special Interest Group of the International Association for the Study of
Pain recently sponsored the development of evidence-based guidelines for the …

Neuropathic pain is accompanied by both positive and negative sensory signs. To explore
the spectrum of sensory abnormalities, 1236 patients with a clinical diagnosis of neuropathic …