[HTML][HTML] Role of the gut microbiota in anticancer therapy: from molecular mechanisms to clinical applications
LY Zhao, JX Mei, G Yu, L Lei, WH Zhang… - … and Targeted Therapy, 2023 - nature.com
In the past period, due to the rapid development of next-generation sequencing technology,
accumulating evidence has clarified the complex role of the human microbiota in the …
accumulating evidence has clarified the complex role of the human microbiota in the …
[HTML][HTML] The translational challenges of precision oncology
The translational challenges in the field of precision oncology are in part related to the
biological complexity and diversity of this disease. Technological advances in genomics …
biological complexity and diversity of this disease. Technological advances in genomics …
Chromothripsis as an on-target consequence of CRISPR–Cas9 genome editing
Genome editing has therapeutic potential for treating genetic diseases and cancer.
However, the currently most practicable approaches rely on the generation of DNA double …
However, the currently most practicable approaches rely on the generation of DNA double …
[HTML][HTML] Signatures of copy number alterations in human cancer
Gains and losses of DNA are prevalent in cancer and emerge as a consequence of inter-
related processes of replication stress, mitotic errors, spindle multipolarity and breakage …
related processes of replication stress, mitotic errors, spindle multipolarity and breakage …
Evolutionary history of transformation from chronic lymphocytic leukemia to Richter syndrome
Richter syndrome (RS) arising from chronic lymphocytic leukemia (CLL) exemplifies an
aggressive malignancy that develops from an indolent neoplasm. To decipher the genetics …
aggressive malignancy that develops from an indolent neoplasm. To decipher the genetics …
[HTML][HTML] Uncovering novel mutational signatures by de novo extraction with SigProfilerExtractor
Mutational signature analysis is commonly performed in cancer genomic studies. Here, we
present SigProfilerExtractor, an automated tool for de novo extraction of mutational …
present SigProfilerExtractor, an automated tool for de novo extraction of mutational …
[HTML][HTML] The landscape of viral associations in human cancers
Here, as part of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, for
which whole-genome and—for a subset—whole-transcriptome sequencing data from 2,658 …
which whole-genome and—for a subset—whole-transcriptome sequencing data from 2,658 …
Structural variants drive context-dependent oncogene activation in cancer
Higher-order chromatin structure is important for the regulation of genes by distal regulatory
sequences,. Structural variants (SVs) that alter three-dimensional (3D) genome organization …
sequences,. Structural variants (SVs) that alter three-dimensional (3D) genome organization …
[HTML][HTML] Artificial intelligence assists precision medicine in cancer treatment
Cancer is a major medical problem worldwide. Due to its high heterogeneity, the use of the
same drugs or surgical methods in patients with the same tumor may have different curative …
same drugs or surgical methods in patients with the same tumor may have different curative …
[HTML][HTML] Targeting Pim kinases in hematological cancers: molecular and clinical review
M Bellon, C Nicot - Molecular Cancer, 2023 - Springer
Decades of research has recognized a solid role for Pim kinases in lymphoproliferative
disorders. Often up-regulated following JAK/STAT and tyrosine kinase receptor signaling …
disorders. Often up-regulated following JAK/STAT and tyrosine kinase receptor signaling …