[HTML][HTML] A compendium of genetic regulatory effects across pig tissues
Abstract The Farm Animal Genotype-Tissue Expression (FarmGTEx) project has been
established to develop a public resource of genetic regulatory variants in livestock, which is …
established to develop a public resource of genetic regulatory variants in livestock, which is …
The 3D-Evo space: evolution of gene expression and alternative splicing regulation
F Mantica, M Irimia - Annual Review of Genetics, 2022 - annualreviews.org
Animal species present relatively high levels of gene conservation, and yet they display a
great variety of cell type and tissue phenotypes. These diverse phenotypes are mainly …
great variety of cell type and tissue phenotypes. These diverse phenotypes are mainly …
Evolution of gene sequence and gene expression are not correlated in yeast
We show that, in yeast, the divergence rate of gene expression is not correlated with that of
its associated coding sequence. Gene essentiality influences both modes of evolution, but …
its associated coding sequence. Gene essentiality influences both modes of evolution, but …
[HTML][HTML] Comparative transcriptome in large-scale human and cattle populations
Background Cross-species comparison of transcriptomes is important for elucidating
evolutionary molecular mechanisms underpinning phenotypic variation between and within …
evolutionary molecular mechanisms underpinning phenotypic variation between and within …
[HTML][HTML] Substantial contribution of genetic variation in the expression of transcription factors to phenotypic variation revealed by eRD-GWAS
Background There are significant limitations in existing methods for the genome-wide
identification of genes whose expression patterns affect traits. Results The transcriptomes of …
identification of genes whose expression patterns affect traits. Results The transcriptomes of …
A comprehensive catalogue of regulatory variants in the cattle transcriptome
Abstract Characterization of genetic regulatory variants acting on the transcriptome of
livestock is essential for interpreting the molecular mechanisms underlying traits of …
livestock is essential for interpreting the molecular mechanisms underlying traits of …
A phylogenetic framework to simulate synthetic interspecies RNA-Seq data
Interspecies RNA-Seq datasets are increasingly common, and have the potential to answer
new questions about the evolution of gene expression. Single-species differential …
new questions about the evolution of gene expression. Single-species differential …
Selective constraints on coding sequences of nervous system genes are a major determinant of duplicate gene retention in vertebrates
The evolutionary history of vertebrates is marked by three ancient whole-genome
duplications: two successive rounds in the ancestor of vertebrates, and a third one specific to …
duplications: two successive rounds in the ancestor of vertebrates, and a third one specific to …
The grayling genome reveals selection on gene expression regulation after whole-genome duplication
Whole-genome duplication (WGD) has been a major evolutionary driver of increased
genomic complexity in vertebrates. One such event occurred in the salmonid family∼ 80 Ma …
genomic complexity in vertebrates. One such event occurred in the salmonid family∼ 80 Ma …
Reduction of complex signaling networks to a representative kernel
JR Kim, J Kim, YK Kwon, HY Lee… - Science …, 2011 - science.org
The network of biomolecular interactions that occurs within cells is large and complex. When
such a network is analyzed, it can be helpful to reduce the complexity of the network to a …
such a network is analyzed, it can be helpful to reduce the complexity of the network to a …