Microglia phenotypes in aging and neurodegenerative diseases

MY Wendimu, SB Hooks - Cells, 2022 - mdpi.com
Neuroinflammation is a hallmark of many neurodegenerative diseases (NDs) and plays a
fundamental role in mediating the onset and progression of disease. Microglia, which …

Diagnosis and treatment of Parkinson disease: a review

MJ Armstrong, MS Okun - Jama, 2020 - jamanetwork.com
Importance Parkinson disease is the most common form of parkinsonism, a group of
neurological disorders with Parkinson disease–like movement problems such as rigidity …

The gut–brain axis and its relation to Parkinson's disease: a review

EM Klann, U Dissanayake, A Gurrala… - Frontiers in aging …, 2022 - frontiersin.org
Parkinson's disease is a chronic neurodegenerative disease characterized by the
accumulation of misfolded alpha-synuclein protein (Lewy bodies) in dopaminergic neurons …

[HTML][HTML] Glucagon-like peptide-1: A multi-faceted anti-inflammatory agent

SF Mehdi, S Pusapati, MS Anwar, D Lohana… - Frontiers in …, 2023 - frontiersin.org
Inflammation contributes to many chronic conditions. It is often associated with circulating
pro-inflammatory cytokines and immune cells. GLP-1 levels correlate with disease severity …

Alpha-synuclein aggregation pathway in Parkinson's disease: current status and novel therapeutic approaches

M Vidović, MG Rikalovic - Cells, 2022 - mdpi.com
Following Alzheimer's, Parkinson's disease (PD) is the second-most common
neurodegenerative disorder, sharing an unclear pathophysiology, a multifactorial profile …

Alpha-synuclein as a biomarker of Parkinson's disease: good, but not good enough

U Ganguly, S Singh, S Pal, S Prasad… - Frontiers in aging …, 2021 - frontiersin.org
Parkinson's disease (PD) is the second most common neurodegenerative disorder of the
elderly, presenting primarily with symptoms of motor impairment. The disease is diagnosed …

The pathology of Parkinson's disease and potential benefit of dietary polyphenols

S Aryal, T Skinner, B Bridges, JT Weber - Molecules, 2020 - mdpi.com
Parkinson's disease (PD) is a progressive neurodegenerative disorder that is characterized
by a loss of dopaminergic neurons, leading to bradykinesia, rigidity, tremor at rest, and …

Overcoming barriers in non-viral gene delivery for neurological applications

A Tasset, A Bellamkonda, W Wang, I Pyatnitskiy… - Nanoscale, 2022 - pubs.rsc.org
Gene therapy for neurological disorders has attracted significant interest as a way to reverse
or stop various disease pathologies. Typical gene therapies involving the central and …

Sex and gender differences in neurodegenerative diseases: challenges for therapeutic opportunities

A Bianco, Y Antonacci, M Liguori - International journal of molecular …, 2023 - mdpi.com
The term “neurodegenerative diseases”(NDs) identifies a group of heterogeneous diseases
characterized by progressive loss of selectively vulnerable populations of neurons, which …

Mass spectrometry–based proteomics analysis of human substantia nigra from Parkinson's disease patients identifies multiple pathways potentially involved in the …

Y Jang, O Pletnikova, JC Troncoso, AY Pantelyat… - Molecular & Cellular …, 2023 - ASBMB
Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder
characterized by the loss of dopaminergic neurons in the substantia nigra (SN) of the brain …