The traditional classification of lung cancer into small cell lung cancer and non‐small cell
lung cancer (NSCLC) has been transformed with the increased understanding of the …

The RAS/MAP kinase and the RAS/PI3K/AKT pathways play a key role in the regulation of
proliferation, differentiation and survival. The induction of these pathways depends on …

Abstract The phosphoinositide 3-kinase (PI3K) pathway is a key signal transduction system
that links oncogenes and multiple receptor classes to many essential cellular functions, and …

There are ample genetic and laboratory studies that suggest the PI3K–Akt pathway is vital to
the growth and survival of cancer cells. Inhibitors targeting this pathway are entering the …

Abstract Phosphatidylinositol 3-kinases (PI3Ks) evolved from a single enzyme that regulates
vesicle trafficking in unicellular eukaryotes into a family of enzymes that regulate cellular …

Lung cancer is the leading cause of cancer death worldwide, accounting for more deaths
than breast, prostate and colon cancer combined. While treatment decisions are determined …

Chromosome aberrations in human solid tumors are hallmarks of gene deregulation and
genome instability. This review summarizes current knowledge regarding aberrations …

Purpose: We have previously identified solute-linked carrier family A1 member 5 (SLC1A5)
as an overexpressed protein in a shotgun proteomic analysis of stage I non–small cell lung …

Lung cancer is the leading cause of cancer-related death in men and women in the United
States, accounting for approximately 28% of total cancer deaths in 2010 despite comprising …

We investigated the frequency and function of mutations and increased copy number of the
PIK3CA gene in lung cancers. PIK3CA mutations are one of the most common gene …