A century old renin–angiotensin system still grows with endless possibilities: AT1 receptor signaling cascades in cardiovascular physiopathology

P Balakumar, G Jagadeesh - Cellular signalling, 2014 - Elsevier
Ang II, the primary effector pleiotropic hormone of the renin–angiotensin system (RAS)
cascade, mediates physiological control of blood pressure and electrolyte balance through …

Oxidative stress, GTPCH1, and endothelial nitric oxide synthase uncoupling in hypertension

Y Wu, Y Ding, T Ramprasath, MH Zou - Antioxidants & redox …, 2021 - liebertpub.com
Significance: Hypertension has major health consequences, which is associated with
endothelial dysfunction. Endothelial nitric oxide synthase (eNOS)-produced nitric oxide (NO) …

Roles of eNOS in atherosclerosis treatment

F Hong, X Liang, W Liu, S Lv, S He, H Kuang… - Inflammation …, 2019 - Springer
Background Atherosclerosis (AS) is the main pathogeny of coronary heart disease, cerebral
infarction and peripheral vascular disease. Endothelial dysfunction is one of the important …

Endothelial nitric oxide synthase: a potential therapeutic target for cerebrovascular diseases

J Zhu, W Song, L Li, X Fan - Molecular brain, 2016 - Springer
Endothelial nitric oxide (NO) is a significant signaling molecule that regulates cerebral blood
flow (CBF), playing a pivotal role in the prevention and treatment of cerebrovascular …

Arginine and nitric oxide synthase: regulatory mechanisms and cardiovascular aspects

J Lorin, M Zeller, JC Guilland, Y Cottin… - Molecular nutrition & …, 2014 - Wiley Online Library
l‐A rginine (l‐A rg) is a conditionally essential amino acid in the human diet. The most
common dietary sources of l‐A rg are meat, poultry and fish. l‐A rg is the precursor for the …

Fish oil and vascular endothelial protection: bench to bedside

P Balakumar, G Taneja - Free Radical Biology and Medicine, 2012 - Elsevier
Fish oil is recommended for the management of hypertriglyceridemia and to prevent
secondary cardiovascular disorders. Fish oil is a major source of ω-3-polyunsaturated fatty …

Circulating microparticles are elevated in treated HIV‐1 infection and are deleterious to endothelial cell function

JG Hijmans, KA Stockelman, V Garcia… - Journal of the …, 2019 - Am Heart Assoc
Background Circulating microparticles have emerged as biomarkers and effectors of
vascular disease. Elevated rates of cardiovascular disease are seen in HIV‐1–seropositive …

TLR4 signaling: a potential therapeutic target in ischemic coronary artery disease

SJ Jia, PP Niu, JZ Cong, BK Zhang, M Zhao - International …, 2014 - Elsevier
Atherosclerosis has been widely considered as a chronic inflammation process, which
triggers a wide range of cardiovascular diseases such as ischemic coronary artery disease …

Simvastatin attenuates TNF‑α‑induced apoptosis in endothelial progenitor cells via the upregulation of SIRT1

G Du, Y Song, T Zhang, L Ma… - International …, 2014 - spandidos-publications.com
Endothelial progenitor cells (EPCs) originate from the bone marrow and can be classified as
either early or late EPCs. The focus of this study was on late EPCs, as they play an important …

Bauhinia championii flavone inhibits apoptosis and autophagy via the PI3K/Akt pathway in myocardial ischemia/reperfusion injury in rats

J Jian, F Xuan, F Qin, R Huang - Drug Design, Development and …, 2015 - Taylor & Francis
This study aimed to determine the effects of Bauhinia championii flavone (BCF) on
myocardial ischemia/reperfusion injury (MI/RI) in rats and to explore potential mechanisms …