Atopic dermatitis: an expanding therapeutic pipeline for a complex disease
T Bieber - Nature reviews Drug discovery, 2022 - nature.com
Atopic dermatitis (AD) is a common chronic inflammatory skin disease with a complex
pathophysiology that underlies a wide spectrum of clinical phenotypes. AD remains …
pathophysiology that underlies a wide spectrum of clinical phenotypes. AD remains …
Emerging biology of sphingosine-1-phosphate: its role in pathogenesis and therapy
Membrane sphingolipids are metabolized to sphingosine-1-phosphate (S1P), a bioactive
lipid mediator that regulates many processes in vertebrate development, physiology, and …
lipid mediator that regulates many processes in vertebrate development, physiology, and …
Inflammation, vitamin B6 and related pathways
PM Ueland, A McCann, Ø Midttun, A Ulvik - Molecular aspects of medicine, 2017 - Elsevier
The active form of vitamin B6, pyridoxal 5′-phosphate (PLP), serves as a co-factor in more
than 150 enzymatic reactions. Plasma PLP has consistently been shown to be low in …
than 150 enzymatic reactions. Plasma PLP has consistently been shown to be low in …
Emerging PET radiotracers and targets for imaging of neuroinflammation in neurodegenerative diseases: outlook beyond TSPO
V Narayanaswami, K Dahl… - Molecular …, 2018 - journals.sagepub.com
The dynamic and multicellular processes of neuroinflammation are mediated by the
nonneuronal cells of the central nervous system, which include astrocytes and the brain's …
nonneuronal cells of the central nervous system, which include astrocytes and the brain's …
[HTML][HTML] Efficacy and safety of etrasimod in a phase 2 randomized trial of patients with ulcerative colitis
WJ Sandborn, L Peyrin-Biroulet, J Zhang, M Chiorean… - Gastroenterology, 2020 - Elsevier
Background & Aims Etrasimod (APD334) is an oral, selective sphingosine 1-phosphate
receptor modulator in development for immune-mediated inflammatory disorders. We …
receptor modulator in development for immune-mediated inflammatory disorders. We …
Angiogenesis and blood-brain barrier permeability in vascular remodeling after stroke
Y Yang, MT Torbey - Current neuropharmacology, 2020 - ingentaconnect.com
Angiogenesis, the growth of new blood vessels, is a natural defense mechanism helping to
restore oxygen and nutrient supply to the affected brain tissue following an ischemic stroke …
restore oxygen and nutrient supply to the affected brain tissue following an ischemic stroke …
Sphingolipids in host–microbial interactions
Highlights•Sphingolipid production is phylogenetically restricted in Bacteria to two
phyla.•Sphingolipid-producing bacteria often associate with eukaryotic hosts.•Many bacterial …
phyla.•Sphingolipid-producing bacteria often associate with eukaryotic hosts.•Many bacterial …
Synthesis and degradation pathways, functions, and pathology of ceramides and epidermal acylceramides
A Kihara - Progress in lipid research, 2016 - Elsevier
Ceramide (Cer) is a structural backbone of sphingolipids and is composed of a long-chain
base and a fatty acid. Existence of a variety of Cer species, which differ in chain-length …
base and a fatty acid. Existence of a variety of Cer species, which differ in chain-length …
HDL-bound sphingosine 1-phosphate acts as a biased agonist for the endothelial cell receptor S1P1 to limit vascular inflammation
S Galvani, M Sanson, VA Blaho, SL Swendeman… - Science …, 2015 - science.org
The sphingosine 1-phosphate receptor 1 (S1P1) is abundant in endothelial cells, where it
regulates vascular development and microvascular barrier function. In investigating the role …
regulates vascular development and microvascular barrier function. In investigating the role …
Functional roles of sphingolipids in immunity and their implication in disease
M Lee, SY Lee, YS Bae - Experimental & molecular medicine, 2023 - nature.com
Sphingolipids, which are components of cellular membranes and organ tissues, can be
synthesized or degraded to modulate cellular responses according to environmental cues …
synthesized or degraded to modulate cellular responses according to environmental cues …