This review provides an overview of the changing US epidemiology of cannabis use and
associated problems. Adults and adolescents increasingly view cannabis as harmless, and …

Since DSM-IV was published in 1994, its approach to substance use disorders has come
under scrutiny. Strengths were identified (notably, reliability and validity of dependence), but …

Background Synthetic cannabinoids (SC) are a heterogeneous group of compounds
developed to probe the endogenous cannabinoid system or as potential therapeutics …

Introduction: Cannabis has been used for medical purposes across the world for centuries.
As states and countries implement medical and recreational cannabis policies, increasing …

Introduction: Despite known sex differences in the endocannabinoid system of animals, little
attention has been paid to sex differences in human's cannabis use patterns and effects. The …

Background The use of cannabis, or marijuana, for medicinal purposes is deeply rooted
though history, dating back to ancient times. It once held a prominent position in the history …

The cannabis withdrawal syndrome (CWS) is a criterion of cannabis use disorders
(CUDs)(Diagnostic and Statistical Manual of Mental Disorders–Fifth Edition) and cannabis …

Sleep is a vital function of the nervous system that contributes to brain and bodily
homeostasis, energy levels, cognitive ability, and other key functions of a variety of …

Introduction: The opioid epidemic has become an immense problem in North America, and
despite decades of research on the most effective means to treat opioid use disorder (OUD) …

Background Cannabis is one of the most widely used drugs worldwide. Cannabis use
disorder is characterised by recurrent use of cannabis that causes significant clinical and …