Despite the success of antiretroviral therapy (ART), people living with HIV continue to suffer
from high burdens of respiratory infections, lung cancers and chronic lung disease at a …

Recruitment and activation of leukocytes are important for elimination of microbes, including
viruses, from infected areas. Chemokines constitute a group of bioactive peptides that …

As genome engineering advances cell-based therapies, a versatile approach to introducing
both CRISPR-Cas9 ribonucleoproteins (RNPs) and therapeutic transgenes into specific …

Angiotensin-converting enzyme 2 (ACE2) is a receptor for SARS-CoV, the novel coronavirus
that causes severe acute respiratory syndrome [Li, W. Moore, MJ, Vasilieva, N., Sui, J …

Mammalian orthoreovirus (reovirus) infects most mammals and is associated with celiac
disease in humans. In mice, reovirus infects the intestine and disseminates systemically to …

Antigenic stimulation of T cells gives rise to short-lived effector cells and long-lived memory
cells. We used two stable isotope-labeling techniques to identify kinetically distinct …

Gene delivery has been extensively investigated for introducing foreign genetic material into
cells to promote expression of therapeutic proteins or to silence relevant genes. This …

The introduction of Highly Active Anti-retroviral Therapy (HAART) has resulted in significant
decreases in morbidity and mortality for subjects infected with HIV. The brain is a major …

HIV/AIDS is still a global threat despite the notable efforts made by the scientific and health
communities to understand viral infection, to design new drugs or to improve existing ones …

The establishment and maintenance of HIV reservoirs that lead to persistent viremia in
patients on antiretroviral drugs remains the greatest challenge of the highly active …