Parkinson's disease is a complex neurodegenerative disorder for which both rare and
common genetic variants contribute to disease risk, onset, and progression. Mutations in …

Oxidative stress is proposed as a regulatory element in ageing and various neurological
disorders. The excess of oxidants causes a reduction of antioxidants, which in turn produce …

Neurodegenerative diseases, the leading cause of morbidity and disability, are gaining
increased attention as they impose a considerable socioeconomic impact, due in part to the …

Neurodegenerative diseases have two general characteristics that are so fundamental we
usually take them for granted. The first is that the pathology associated with the disease only …

In addition to ATP synthesis, mitochondria are highly dynamic organelles that modulate
apoptosis, ferroptosis, and inflammasome activation. Through executing these varied …

Aging and neurodegenerative diseases share common hallmarks, including mitochondrial
dysfunction and protein aggregation. Moreover, one of the major issues of the demographic …

Neurodegenerative diseases are progressive degenerative conditions characterized by the
functional deterioration and ultimate loss of neurons. These incurable and debilitating …

The central nervous system (CNS) encompasses the brain and spinal cord and is
considered the processing center and the most vital part of human body. The central …

Computational drug repurposing aims to identify new indications for existing drugs by
utilizing high-throughput data, often in the form of biomedical knowledge graphs. However …

Following Alzheimer's, Parkinson's disease (PD) is the second-most common
neurodegenerative disorder, sharing an unclear pathophysiology, a multifactorial profile …