Acute lymphoblastic leukemia in children

SP Hunger, CG Mullighan - New England Journal of Medicine, 2015 - Mass Medical Soc
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Genetic basis of acute lymphoblastic leukemia

I Iacobucci, CG Mullighan - Journal of Clinical Oncology, 2017 - ascopubs.org
Acute lymphoblastic leukemia (ALL) is the most common childhood cancer, and despite cure
rates exceeding 90% in children, it remains an important cause of morbidity and mortality in …

Childhood acute lymphoblastic leukemia: progress through collaboration

CH Pui, JJ Yang, SP Hunger, R Pieters… - Journal of Clinical …, 2015 - ascopubs.org
Purpose To review the impact of collaborative studies on advances in the biology and
treatment of acute lymphoblastic leukemia (ALL) in children and adolescents. Methods A …

Treatment and biology of pediatric acute lymphoblastic leukemia

M Kato, A Manabe - Pediatrics International, 2018 - Wiley Online Library
Acute lymphoblastic leukemia (ALL) is the most common pediatric malignancy. In the past
ALL was intractable but now the survival probability is as high as 80–90%. Improved …

The genomic landscape of hypodiploid acute lymphoblastic leukemia

L Holmfeldt, L Wei, E Diaz-Flores, M Walsh, J Zhang… - Nature …, 2013 - nature.com
The genetic basis of hypodiploid acute lymphoblastic leukemia (ALL), a subtype of ALL
characterized by aneuploidy and poor outcome, is unknown. Genomic profiling of 124 …

Pediatric acute lymphoblastic leukemia, version 2.2020, NCCN clinical practice guidelines in oncology

P Brown, H Inaba, C Annesley, J Beck… - Journal of the National …, 2020 - jnccn.org
Acute lymphoblastic leukemia (ALL) is the most common pediatric malignancy.
Advancements in technology that enhance our understanding of the biology of the disease …

Pediatric acute lymphoblastic leukemia: where are we going and how do we get there?

CH Pui, CG Mullighan, WE Evans… - Blood, The Journal of …, 2012 - ashpublications.org
Improved supportive care, more precise risk stratification, and personalized chemotherapy
based on the characteristics of leukemic cells and hosts (eg, pharmacokinetics and …

Biology, risk stratification, and therapy of pediatric acute leukemias: an update

CH Pui, WL Carroll, S Meshinchi… - Journal of clinical …, 2011 - ascopubs.org
Purpose We review recent advances in the biologic understanding and treatment of
childhood acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML), identify …

Redefining ALL classification: toward detecting high-risk ALL and implementing precision medicine

SP Hunger, CG Mullighan - Blood, The Journal of the American …, 2015 - ashpublications.org
Acute lymphoblastic leukemia (ALL) is the commonest childhood tumor and remains a
leading cause of cancer death in the young. In the last decade, microarray and sequencing …

Acute lymphoblastic leukaemia

CH Pui, LL Robison, AT Look - The Lancet, 2008 - thelancet.com
Acute lymphoblastic leukaemia, a malignant disorder of lymphoid progenitor cells, affects
both children and adults, with peak prevalence between the ages of 2 and 5 years. Steady …