Cardiac and skeletal striated muscles are intricately designed machines responsible for
muscle contraction. Coordination of the basic contractile unit, the sarcomere, and the …

Neurons, perhaps more than any other cell type, depend on mitochondrial trafficking for their
survival. Recent studies have elucidated a motor/adaptor complex on the mitochondrial …

Mitochondria play a critical role in maintaining cellular function by ATP production. They are
also a source of reactive oxygen species (ROS) and proapoptotic factors. The role of …

Abstract Analysis of mitochondrial function is central to the study of intracellular energy
metabolism, mechanisms of cell death and pathophysiology of a variety of human diseases …

Intermediate filaments (IFs) constitute a major structural element of animal cells. They build
two distinct systems, one in the nucleus and one in the cytoplasm. In both cases, their major …

Desmin is the primary intermediate filament (IF) of cardiac, skeletal, and smooth muscle. By
linking the contractile myofibrils to the sarcolemma and cellular organelles, desmin IF …

▪ Abstract Striated muscle is an intricate, efficient, and precise machine that contains
complex interconnected cytoskeletal networks critical for its contractile activity. The …

During postnatal cardiac development, cardiomyocytes mature and turn into adult ones.
Hence, all cellular properties, including morphology, structure, physiology and metabolism …

Measurements of glycolysis and mitochondrial function are required to quantify energy
metabolism in a wide variety of cellular contexts. In human pluripotent stem cells (hPSCs) …

Autophagy and epithelial to mesenchymal transition (EMT) are major biological processes in
cancer. Autophagy is a catabolic pathway that aids cancer cells to overcome intracellular or …