Rational design of nanocarriers for intracellular protein delivery
Protein/antibody therapeutics have exhibited the advantages of high specificity and activity
even at an extremely low concentration compared to small molecule drugs. However, they …
even at an extremely low concentration compared to small molecule drugs. However, they …
Polymeric Nanoparticles for Drug Delivery
MA Beach, U Nayanathara, Y Gao, C Zhang… - Chemical …, 2024 - ACS Publications
The recent emergence of nanomedicine has revolutionized the therapeutic landscape and
necessitated the creation of more sophisticated drug delivery systems. Polymeric …
necessitated the creation of more sophisticated drug delivery systems. Polymeric …
[HTML][HTML] SARS-CoV-2 ORF3b is a potent interferon antagonist whose activity is increased by a naturally occurring elongation variant
Y Konno, I Kimura, K Uriu, M Fukushi, T Irie… - Cell reports, 2020 - cell.com
One of the features distinguishing SARS-CoV-2 from its more pathogenic counterpart SARS-
CoV is the presence of premature stop codons in its ORF3b gene. Here, we show that SARS …
CoV is the presence of premature stop codons in its ORF3b gene. Here, we show that SARS …
[HTML][HTML] Improved prime editors enable pathogenic allele correction and cancer modelling in adult mice
Prime editors (PEs) mediate genome modification without utilizing double-stranded DNA
breaks or exogenous donor DNA as a template. PEs facilitate nucleotide substitutions or …
breaks or exogenous donor DNA as a template. PEs facilitate nucleotide substitutions or …
[HTML][HTML] Colloidal capsules: nano-and microcapsules with colloidal particle shells
Utilizing colloidal particles for the assembly of the shell of nano-and microcapsules holds
great promise for the tailor-made design of new functional materials. Increasing research …
great promise for the tailor-made design of new functional materials. Increasing research …
Evolution and clinical translation of drug delivery nanomaterials
With the advent of technology, the role of nanomaterials in medicine has grown
exponentially in the last few decades. The main advantage of such materials has been …
exponentially in the last few decades. The main advantage of such materials has been …
Bypassing endocytosis: direct cytosolic delivery of proteins
Therapeutic proteins have increased dramatically in both number and frequency of use in
recent years, primarily owing to advances in protein engineering. Protein therapy provides …
recent years, primarily owing to advances in protein engineering. Protein therapy provides …
Nuclear localization signal-tagged systems: Relevant nuclear import principles in the context of current therapeutic design
Nuclear targeting of therapeutics provides a strategy for enhancing efficacy of molecules
active in the nucleus and minimizing off-target effects.'Active'nuclear-directed transport and …
active in the nucleus and minimizing off-target effects.'Active'nuclear-directed transport and …
Protein delivery into cells using inorganic nanoparticle–protein supramolecular assemblies
The delivery of proteins into cells is a potential game changer for a wide array of therapeutic
purposes, including cancer therapy, immunomodulation and treatment of inherited diseases …
purposes, including cancer therapy, immunomodulation and treatment of inherited diseases …
General Strategy for Direct Cytosolic Protein Delivery via Protein–Nanoparticle Co-engineering
Endosomal entrapment is a key hurdle for most intracellular protein-based therapeutic
strategies. We report a general strategy for efficient delivery of proteins to the cytosol through …
strategies. We report a general strategy for efficient delivery of proteins to the cytosol through …