The mechanisms and roles of selective autophagy in mammals
JNS Vargas, M Hamasaki, T Kawabata… - … reviews Molecular cell …, 2023 - nature.com
Autophagy is a process that targets various intracellular elements for degradation.
Autophagy can be non-selective—associated with the indiscriminate engulfment of cytosolic …
Autophagy can be non-selective—associated with the indiscriminate engulfment of cytosolic …
[HTML][HTML] Iron metabolism in ferroptosis
Ferroptosis is a form of regulated cell death that is characterized by iron-dependent
oxidative damage and subsequent plasma membrane ruptures and the release of damage …
oxidative damage and subsequent plasma membrane ruptures and the release of damage …
NRF2 controls iron homeostasis and ferroptosis through HERC2 and VAMP8
Enhancing the intracellular labile iron pool (LIP) represents a powerful, yet untapped
strategy for driving ferroptotic death of cancer cells. Here, we show that NRF2 maintains iron …
strategy for driving ferroptotic death of cancer cells. Here, we show that NRF2 maintains iron …
Inhibiting ferroptosis through disrupting the NCOA4–FTH1 interaction: a new mechanism of action
Ferroptosis is an iron-dependent form of oxidative cell death, and the inhibition of ferroptosis
is a promising strategy with which to prevent and treat neurological diseases. Herein we …
is a promising strategy with which to prevent and treat neurological diseases. Herein we …
Ferritinophagy is involved in the zinc oxide nanoparticles-induced ferroptosis of vascular endothelial cells
Zinc oxide nanoparticles (ZnONPs) hold great promise for biomedical applications. Previous
studies have revealed that ZnONPs exposure can induce toxicity in endothelial cells, but the …
studies have revealed that ZnONPs exposure can induce toxicity in endothelial cells, but the …
[HTML][HTML] Iron metabolism and iron disorders revisited in the hepcidin era
C Camaschella, A Nai, L Silvestri - Haematologica, 2020 - ncbi.nlm.nih.gov
Iron is biologically essential, but also potentially toxic; as such it is tightly controlled at cell
and systemic levels to prevent both deficiency and overload. Iron regulatory proteins post …
and systemic levels to prevent both deficiency and overload. Iron regulatory proteins post …
[HTML][HTML] Autophagy-dependent ferroptosis: machinery and regulation
Macroautophagy (hereafter referred to as autophagy) is an evolutionarily conserved cellular
process capable of degrading various biological molecules (eg, protein, glycogen, lipids …
process capable of degrading various biological molecules (eg, protein, glycogen, lipids …
Targeting autophagy in cancer: recent advances and future directions
RK Amaravadi, AC Kimmelman, J Debnath - Cancer discovery, 2019 - AACR
Autophagy, a multistep lysosomal degradation pathway that supports nutrient recycling and
metabolic adaptation, has been implicated as a process that regulates cancer. Although …
metabolic adaptation, has been implicated as a process that regulates cancer. Although …
Nuclear receptor coactivator 4-mediated ferritinophagy contributes to cerebral ischemia-induced ferroptosis in ischemic stroke
C Li, G Sun, B Chen, L Xu, Y Ye, J He, Z Bao… - Pharmacological …, 2021 - Elsevier
Ischemic stroke poses a significant health risk due to its high rate of disability and mortality.
To address this problem, several therapeutic approaches have been proposed, including …
To address this problem, several therapeutic approaches have been proposed, including …
Iron deficiency
C Camaschella - Blood, The Journal of the American Society of …, 2019 - ashpublications.org
Abstract Iron deficiency anemia affects> 1.2 billions individuals worldwide, and iron
deficiency in the absence of anemia is even more frequent. Total-body (absolute) iron …
deficiency in the absence of anemia is even more frequent. Total-body (absolute) iron …