Sarcopenia represents a muscle-wasting syndrome characterized by progressive and
generalized degenerative loss of skeletal muscle mass, quality, and strength occurring …

Autophagy is the major intracellular degradation system, by which cytoplasmic materials are
delivered to and degraded in the lysosome. As a quality control mechanism for cytoplasmic …

Abstract Calcium (Ca 2+) plays a central role in cardiomyocyte excitation-contraction
coupling. To ensure an optimal electrical impulse propagation and cardiac contraction, Ca …

Reperfusion may induce additional cell death in patients with acute myocardial infarction
receiving primary angioplasty or thrombolysis. Altered intracellular Ca2+ handling was …

Abstract Loss of calcium (Ca2+) homeostasis contributes through different mechanisms to
cell death occurring during the first minutes of reperfusion. One of them is an unregulated …

Calpain plays a critical role in cardiomyopathic changes in type 1 diabetes (T1D). This study
investigated how calpain regulates mitochondrial reactive oxygen species (ROS) generation …

Phospholamban (PLN) is a phosphoprotein in cardiac sarcoplasmic reticulum (SR) that is a
reversible regulator of the Ca2+-ATPase (SERCA2a) activity and cardiac contractility …

Glia form a central component of the nervous system whose varied activities sustain an
environment that is optimised for healthy development and neuronal function. Alpha-amino …

Paraptosis is a type of programmed cell death that is characterized by dilation of the
endoplasmic reticulum (ER) and/or mitochondria. Since paraptosis is morphologically and …

Calpains are ubiquitous non-lysosomal Ca 2+-dependent cysteine proteases also present in
myocardial cytosol and mitochondria. Numerous experimental studies reveal an essential …