Organ-specific features of natural killer cells

FD Shi, HG Ljunggren, A La Cava… - Nature Reviews …, 2011 - nature.com
Natural killer (NK) cells can be swiftly mobilized by danger signals and are among the
earliest arrivals at target organs of disease. However, the role of NK cells in mounting …

Immune system and hepatocellular carcinoma (HCC): new insights into HCC progression

M Kotsari, V Dimopoulou, J Koskinas… - International Journal of …, 2023 - mdpi.com
According to the WHO's recently released worldwide cancer data for 2020, liver cancer
ranks sixth in morbidity and third in mortality among all malignancies. Hepatocellular …

Anti-inflammatory and immunomodulatory mechanisms of atorvastatin in a murine model of traumatic brain injury

X Xu, W Gao, S Cheng, D Yin, F Li, Y Wu, D Sun… - Journal of …, 2017 - Springer
Background Neuroinflammation is an important secondary injury mechanism that has dual
beneficial and detrimental roles in the pathophysiology of traumatic brain injury (TBI) …

CD56brightperforinlow noncytotoxic human NK cells are abundant in both healthy and neoplastic solid tissues and recirculate to secondary lymphoid organs via …

P Carrega, I Bonaccorsi, E Di Carlo… - The Journal of …, 2014 - journals.aai.org
As limited information is available regarding the distribution and trafficking of NK cells
among solid organs, we have analyzed a wide array of tissues derived from different human …

Regulation of NK cell activation and effector functions by the IL-12 family of cytokines: the case of IL-27

NW Zwirner, A Ziblat - Frontiers in immunology, 2017 - frontiersin.org
Natural killer (NK) cells are characterized by their ability to detect and induce apoptosis of
susceptible target cells and by secretion of immunoregulatory cytokines such as IFN-γ …

Cytokine regulation of natural killer cell effector functions

NW Zwirner, CI Domaica - Biofactors, 2010 - Wiley Online Library
Initially described as effectors of natural cytotoxicity and critical players for the control of viral
infections and tumor growth, recent investigations unraveled more widespread functions for …

NK cells in autoimmune diseases: Linking innate and adaptive immune responses

E Gianchecchi, DV Delfino, A Fierabracci - Autoimmunity Reviews, 2018 - Elsevier
The pathogenesis of autoimmunity remains to be fully elucidated, although the contribution
of genetic and environmental factors is generally recognized. Despite autoimmune …

Low NKp30, NKp46 and NKG2D expression and reduced cytotoxic activity on NK cells in cervical cancer and precursor lesions

T Garcia-Iglesias, A del Toro-Arreola… - BMC cancer, 2009 - Springer
Background Persistent high risk HPV infection can lead to cervical cancer, the second most
common malignant tumor in women worldwide. NK cells play a crucial role against tumors …

Virus–host interactions in foot-and-mouth disease virus infection

K Li, C Wang, F Yang, W Cao, Z Zhu… - Frontiers in …, 2021 - frontiersin.org
Foot-and-mouth disease (FMD) is a highly contagious disease of cloven-hoofed animals,
which has been regarded as a persistent challenge for the livestock industry in many …

Activating receptors promote NK cell expansion for maintenance, IL-10 production, and CD8 T cell regulation during viral infection

SH Lee, KS Kim, N Fodil-Cornu, SM Vidal… - Journal of Experimental …, 2009 - rupress.org
Natural killer (NK) cells have the potential to deliver both direct antimicrobial effects and
regulate adaptive immune responses, but NK cell yields have been reported to vary greatly …