Cardiovascular disease is a leading cause of death worldwide and accounts for> 17.3
million deaths per year, with an estimated increase in incidence to 23.6 million by 2030 …

Adenosine triphosphate (ATP) has been well established as an important extracellular
ligand of autocrine signaling, intercellular communication, and neurotransmission with …

Pannexins are large-pore forming channels responsible for ATP release under a variety of
physiological and pathological conditions. Although predicted to share similar membrane …

Three family members compose the pannexin family of channel-forming glycoproteins
(Panx1, Panx2 and Panx3). Their primary function is defined by their capacity to form single …

Purinergic signaling plays important roles in control of vascular tone and remodeling. There
is dual control of vascular tone by ATP released as a cotransmitter with noradrenaline from …

Abstract Models of unregulated nitric oxide (NO) diffusion do not consistently account for the
biochemistry of NO synthase (NOS)-dependent signalling in many cell systems,,. For …

Abstract The nucleotide adenosine 5′-triphosphate (ATP) has classically been considered
the cell's primary energy currency. Importantly, a novel role for ATP as an extracellular …

Abstract Pannexin-1 (Panx1) channels have been shown to regulate leukocyte trafficking
and tissue inflammation but the mechanism of Panx1 in chronic vascular diseases like …

Extracellular nucleotides and nucleosides promote a vast range of physiological responses,
via activation of cell surface purinergic receptors. Virtually all tissues and cell types exhibit …

Pannexin 1 (PANX1) channels mediate release of ATP, a" find-me" signal that recruits
macrophages to apoptotic cells; PANX1 activation during apoptosis requires caspase …