The nuclear factor-kappaB (NF-κB) signaling pathway is considered as a potential
therapeutic target in cancer therapy. It has been well established that transcription factor NF …

Gastrointestinal (GI) tumors (cancers of the esophagus, gastric, liver, pancreas, colon, and
rectum) contribute to a large number of deaths worldwide. STAT3 is an oncogenic …

The use of derivatives of natural and synthetic origin has gained attention because of their
therapeutic effects against human diseases. Coumarins are one of the most common …

Cancer is a major cause of death worldwide, with an increasing number of cases being
reported annually. The elevated rate of mortality necessitates a global challenge to explore …

Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) is responsible for the
regulation of a large number of genes that are involved in important physiological …

Signal transducer and activator of transcription (STAT) proteins are latent transcription
factors that reside in the cytoplasm of several types of cells. In canonical signaling, upon …

Cancer is a prominent cause of death in global. Currently, the numbers of drugs that are in
clinical practice are having a high prevalence of side effect and multidrug resistance …

Overactivation of PI3K/Akt/mTOR is linked with carcinogenesis and serves a potential
molecular therapeutic target in treatment of various cancers. Herein, we report the synthesis …

Aberrant activation of NF-κB is linked with the progression of human malignancies including
hepatocellular carcinoma (HCC), and blockade of NF-κB signaling could be a potential …

Sažetak Coumarins, natural or synthetic, due to their wide range of biological activities, have
become an interesting subject of investigation for many researchers. Coumarin scaffold has …