The main goal of chemotherapeutic drugs is to induce massive cell death in tumors.
Cisplatin is an antitumor drug widely used to treat several types of cancer. Despite its …

Apoptosis is the programmed cell death which maintains the healthy survival/death balance
in metazoan cells. Defect in apoptosis can cause cancer or autoimmunity, while enhanced …

Cisplatin is one of the most commonly used chemotherapy drugs, treating a wide range of
cancer types. Unfortunately, many cancers initially respond to platinum treatment but when …

One-carbon metabolism involving the folate and methionine cycles integrates nutritional
status from amino acids, glucose and vitamins, and generates diverse outputs, such as the …

The platinum derivative cis-diamminedichloroplatinum (II), best known as cisplatin, is
currently employed for the clinical management of patients affected by testicular, ovarian …

The platinum analogues, cisplatin and carboplatin, are among the most widely used
chemotherapeutic agents in oncology. Both agents have a broad spectrum of clinical activity …

Platinum-based drugs, and in particular cis-diamminedichloroplatinum (II)(best known as
cisplatin), are employed for the treatment of a wide array of solid malignancies, including …

Gastric cancer is the second most frequent cause of cancer death worldwide, although much
geographical variation in incidence exists. Prevention and personalised treatment are …

Gastric cancer is an active topic of clinical and basic research due to high morbidity and
mortality. To date, gastrectomy and chemotherapy are the only therapeutic options for gastric …

Resistance to chemotherapy limits the effectiveness of anti‐cancer drug treatment. Tumours
may be intrinsically drug‐resistant or develop resistance to chemotherapy during treatment …