Making sense of the ageing methylome
Over time, the human DNA methylation landscape accrues substantial damage, which has
been associated with a broad range of age-related diseases, including cardiovascular …
been associated with a broad range of age-related diseases, including cardiovascular …
A road map for understanding molecular and genetic determinants of osteoporosis
Osteoporosis is a highly prevalent disorder characterized by low bone mineral density and
an increased risk of fracture, termed osteoporotic fracture. Notably, bone mineral density …
an increased risk of fracture, termed osteoporotic fracture. Notably, bone mineral density …
Skeletal aging and osteoporosis: mechanisms and therapeutics
A Chandra, J Rajawat - International journal of molecular sciences, 2021 - mdpi.com
Bone is a dynamic organ maintained by tightly regulated mechanisms. With old age, bone
homeostasis, which is maintained by an intricate balance between bone formation and bone …
homeostasis, which is maintained by an intricate balance between bone formation and bone …
Bone aging, cellular senescence, and osteoporosis
RJ Pignolo, SF Law, A Chandra - Journal of Bone and Mineral …, 2021 - academic.oup.com
Changes in aging bone that lead to osteoporosis are mediated at multiple levels, including
hormonal alterations, skeletal unloading, and accumulation of senescent cells. This …
hormonal alterations, skeletal unloading, and accumulation of senescent cells. This …
The osteological paradox 20 years later: past perspectives, future directions
SN DeWitte, CM Stojanowski - Journal of Archaeological Research, 2015 - Springer
More than 20 years ago, Wood et al.(Curr Anthropol 33: 343–370, 1992) published “The
Osteological Paradox: Problems of Inferring Prehistoric Health from Skeletal Samples,” in …
Osteological Paradox: Problems of Inferring Prehistoric Health from Skeletal Samples,” in …
Phenotypic instability of chondrocytes in osteoarthritis: on a path to hypertrophy
P Singh, KB Marcu, MB Goldring… - Annals of the New York …, 2019 - Wiley Online Library
Articular chondrocytes are quiescent, fully differentiated cells responsible for the
homeostasis of adult articular cartilage by maintaining cellular survival functions and the fine …
homeostasis of adult articular cartilage by maintaining cellular survival functions and the fine …
Epigenetic mechanisms of aging and aging-associated diseases
A la Torre, F Lo Vecchio, A Greco - Cells, 2023 - mdpi.com
Aging is an inevitable outcome of life, characterized by a progressive decline in tissue and
organ function. At a molecular level, it is marked by the gradual alterations of biomolecules …
organ function. At a molecular level, it is marked by the gradual alterations of biomolecules …
Reconstructing the DNA methylation maps of the Neandertal and the Denisovan
Ancient DNA sequencing has recently provided high-coverage archaic human genomes.
However, the evolution of epigenetic regulation along the human lineage remains largely …
However, the evolution of epigenetic regulation along the human lineage remains largely …
Nuclear mechanosensing controls MSC osteogenic potential through HDAC epigenetic remodeling
AR Killaars, CJ Walker… - Proceedings of the …, 2020 - National Acad Sciences
Cells sense mechanical cues from the extracellular matrix to regulate cellular behavior and
maintain tissue homeostasis. The nucleus has been implicated as a key mechanosensor …
maintain tissue homeostasis. The nucleus has been implicated as a key mechanosensor …
The roles of epigenetics regulation in bone metabolism and osteoporosis
F Xu, W Li, X Yang, L Na, L Chen, G Liu - Frontiers in cell and …, 2021 - frontiersin.org
Osteoporosis is a metabolic disease characterized by decreased bone mineral density and
the destruction of bone microstructure, which can lead to increased bone fragility and risk of …
the destruction of bone microstructure, which can lead to increased bone fragility and risk of …