The idea that memory is stored in the brain as physical alterations goes back at least as far
as Plato, but further conceptualization of this idea had to wait until the 20 th century when …

The great potential for NMDA receptor modulators as druggable targets in
neurodegenerative disorders has been met with limited success. Considered one of the rare …

Pattern separation (PS) has been defined as a process of reducing overlap between similar
input patterns to minimize interference amongst stored representations. The present article …

Memory and perception have long been considered separate cognitive processes, and
amnesia resulting from medial temporal lobe (MTL) damage is thought to reflect damage to …

Over recent years, accumulated evidence suggests that autophagy induction is protective in
animal models of a number of neurodegenerative diseases. Intense research in the field has …

People perform better on tests of delayed free recall if learning is followed immediately by a
short wakeful rest than by a short period of sensory stimulation. Animal and human work …

A fundamental assumption underlying most current theories of amnesia is that memory
impairments arise because previously studied information either is lost rapidly or is made …

Translational recognition memory research makes frequent use of the Novel Object
Recognition (NOR) paradigm in which animals are simultaneously presented with one new …

With the accumulation of our knowledge about how memories are formed, consolidated,
retrieved, and updated, neuroscience is now reaching a point where discrete memories can …

Transgenic mouse models of Alzheimer's disease (AD) with abundant β-amyloid develop
memory impairments. However, multiple nonmnemonic cognitive domains such as attention …