Tuberculosis (TB) remains one of the leading public health problems worldwide. Declared
as a global emergency in 1993 by the WHO, its control is hampered by the emergence of …

Arylamine N‐acetyltransferases (NAT s) are polymorphic drug‐metabolizing enzymes,
acetylating arylamine carcinogens and drugs including hydralazine and sulphonamides …

Mycolic acids are the major lipid components of the unique mycobacterial cell wall
responsible for the protection of the tuberculosis bacilli from many outside threats. Mycolic …

Mycobacterium tuberculosis, the bacterium that causes tuberculosis, imports and
metabolizes host cholesterol during infection. This ability is important in the chronic phase of …

Arylamine N-acetyltransferases (NATs) catalyse the N-acetylation of arylamines,
arylhydroxylamines and arylhydrazines with the acetyl group being transferred from …

Cyclic AMP synthesized by Mycobacterium tuberculosis has been shown to play a role in
pathogenesis. However, the high levels of intracellular cAMP found in both pathogenic and …

Tuberculosis (TB), although a curable disease, is still one of the most difficult infections to
treat. Mycobacterium tuberculosis infects 10 million people worldwide and kills 1.5 million …

ABSTRACT A defining feature of mycobacterial redox metabolism is the use of an unusual
deazaflavin cofactor, F420. This cofactor enhances the persistence of environmental and …

Arylamine N‐acetyltransferase (NAT) plays an important role in metabolism and
detoxification of many compounds including drugs and environmental carcinogens through …

New anti-tubercular drugs and drug targets are urgently needed to reduce the time for
treatment and also to identify agents that will be effective against Mycobacterium …