Creatine, a naturally occurring nitrogenous organic acid found in animal tissues, has been
found to play key roles in the brain including buffering energy supply, improving …

A growing body of epidemiological and research data has associated neurotropic viruses
with accelerated brain aging and increased risk of neurodegenerative disorders. Many …

Background and Aim. Depression is a social problem with high economic burden in the
society. Finding an effective agent with high efficacy and few side effects is therefore …

Ketamine has emerged as a novel strategy to treat refractory depression, producing rapid
remission, but elicits some side effects that limit its use. In an attempt to investigate a safer …

Creatine monohydrate is actively being researched for its antidepressant effects, yet little is
known about the link between dietary creatine and depression risk. This study examines the …

The activation of AMPA receptors and mTOR signaling has been reported as mechanisms
underlying the antidepressant effects of fast-acting agents, specially the NMDA receptor …

The ability of the N-methyl-d-aspartate receptor antagonist ketamine to induce a rapid and
sustained antidepressant effect has led to a surge in pre-clinical studies investigating …

Major depressive disorder (MDD) often begins during adolescence and is projected to
become the leading cause of global disease burden by the year 2030. Yet, approximately …

Background: Chaihu-Shugan-San is a classical prescription to treat depression. According
to the traditional Chinese medicine (TCM) principle, the 2 decomposed recipes in Chaihu …

Creatine has been proposed to exert beneficial effects in the management of depression,
but the cell signaling pathways implicated in its antidepressant effects are not well …