Progress in proteomics research has led to a demand for powerful analytical tools with high
separation efficiency and sensitivity for confident identification and quantification of proteins …

Top‐down proteomics is emerging as a preferred approach to investigate biological
systems, with objectives ranging from the detailed assessment of a single protein …

Polyubiquitination is an important post-translational modification (PTM) that regulates
various biological functions. The linkage sites and topologies of polyubiquitination chains …

Seminal plasma is a critical and complex fluid that carries sperm to eggs to initiate the
fertilization process. Here, we present a top-down mass spectrometry (TDMS) strategy for …

Fluorescein isothiocyanate-labeled insulin (FITC-insulin) has been widely used for
bioanalytical applications. Due to the high cost of commercial FITC-insulin and tedious …

A top-down proteomic strategy with semiautomated analysis of data sets has proven
successful for the global identification of truncated proteins without the use of chemical …

Regioselective halogenation of organic compounds using non-toxic halide salts and oxygen
in aqueous media at ambient temperatures–a tough task for conventional chemical …

Top-down mass spectrometry (MS) is an increasingly important technique for protein
characterization. However, in many biological MS experiments, the practicality of applying …

Ultraviolet photodissociation (UVPD) mass spectrometry has gained attention in recent
years for its ability to provide high sequence coverage of intact proteins. However …

Purpose Diverse groups of proteins play integral roles in both the physiology and
pathophysiology of the retina. However, thorough proteomic analyses of retinas of …