Autophagy in major human diseases
Autophagy is a core molecular pathway for the preservation of cellular and organismal
homeostasis. Pharmacological and genetic interventions impairing autophagy responses …
homeostasis. Pharmacological and genetic interventions impairing autophagy responses …
Autophagy in metabolic disease and ageing
M Kitada, D Koya - Nature Reviews Endocrinology, 2021 - nature.com
Autophagy is an evolutionarily conserved, lysosome-dependent catabolic process whereby
cytoplasmic components, including damaged organelles, protein aggregates and lipid …
cytoplasmic components, including damaged organelles, protein aggregates and lipid …
Copper-dependent autophagic degradation of GPX4 drives ferroptosis
Ferroptosis is a type of iron-dependent regulated cell death characterized by unrestricted
lipid peroxidation and membrane damage. Although GPX4 (glutathione peroxidase 4) plays …
lipid peroxidation and membrane damage. Although GPX4 (glutathione peroxidase 4) plays …
SARS-CoV-2 infection induces DNA damage, through CHK1 degradation and impaired 53BP1 recruitment, and cellular senescence
U Gioia, S Tavella, P Martínez-Orellana, G Cicio… - Nature Cell …, 2023 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the RNA virus
responsible for the coronavirus disease 2019 (COVID-19) pandemic. Although SARS-CoV-2 …
responsible for the coronavirus disease 2019 (COVID-19) pandemic. Although SARS-CoV-2 …
SARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals
Viruses manipulate cellular metabolism and macromolecule recycling processes like
autophagy. Dysregulated metabolism might lead to excessive inflammatory and …
autophagy. Dysregulated metabolism might lead to excessive inflammatory and …
Mechanisms of selective autophagy
T Lamark, T Johansen - Annual review of cell and …, 2021 - annualreviews.org
Selective autophagy is the lysosomal degradation of specific intracellular components
sequestered into autophagosomes, late endosomes, or lysosomes through the activity of …
sequestered into autophagosomes, late endosomes, or lysosomes through the activity of …
SARS-CoV-2 non-structural protein 6 triggers NLRP3-dependent pyroptosis by targeting ATP6AP1
A recent mutation analysis suggested that Non-Structural Protein 6 (NSP6) of the Severe
Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a key determinant of the viral …
Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a key determinant of the viral …
Mechanisms governing autophagosome biogenesis
H Nakatogawa - Nature reviews Molecular cell biology, 2020 - nature.com
Autophagosomes are double-membrane vesicles newly formed during autophagy to engulf
a wide range of intracellular material and transport this autophagic cargo to lysosomes (or …
a wide range of intracellular material and transport this autophagic cargo to lysosomes (or …
Organelle-specific regulation of ferroptosis
Ferroptosis, a cell death modality characterized by iron-dependent lipid peroxidation, is
involved in the development of multiple pathological conditions, including ischemic tissue …
involved in the development of multiple pathological conditions, including ischemic tissue …
[HTML][HTML] Programmed cell death tunes tumor immunity
The demise of cells in various ways enables the body to clear unwanted cells. Studies over
the years revealed distinctive molecular mechanisms and functional consequences of …
the years revealed distinctive molecular mechanisms and functional consequences of …