Lasting impact of general anaesthesia on the brain: mechanisms and relevance
L Vutskits, Z Xie - Nature Reviews Neuroscience, 2016 - nature.com
General anaesthesia is usually considered to safely induce a reversible brain state allowing
the performance of surgery under optimal conditions. An increasing number of clinical and …
the performance of surgery under optimal conditions. An increasing number of clinical and …
Retinoblastoma
Retinoblastoma is a rare cancer of the infant retina that is diagnosed in approximately 8,000
children each year worldwide. It forms when both retinoblastoma gene (RB1) alleles are …
children each year worldwide. It forms when both retinoblastoma gene (RB1) alleles are …
Neurodevelopmental outcome at 5 years of age after general anaesthesia or awake-regional anaesthesia in infancy (GAS): an international, multicentre, randomised …
Background In laboratory animals, exposure to most general anaesthetics leads to
neurotoxicity manifested by neuronal cell death and abnormal behaviour and cognition …
neurotoxicity manifested by neuronal cell death and abnormal behaviour and cognition …
Neuropsychological and behavioral outcomes after exposure of young children to procedures requiring general anesthesia: the Mayo Anesthesia Safety in Kids …
DO Warner, MJ Zaccariello, SK Katusic… - …, 2018 - pubs.asahq.org
Background Few studies of how exposure of children to anesthesia may affect
neurodevelopment employ comprehensive neuropsychological assessments. This study …
neurodevelopment employ comprehensive neuropsychological assessments. This study …
Association between a single general anesthesia exposure before age 36 months and neurocognitive outcomes in later childhood
Importance Exposure of young animals to commonly used anesthetics causes neurotoxicity
including impaired neurocognitive function and abnormal behavior. The potential …
including impaired neurocognitive function and abnormal behavior. The potential …
Neurodevelopmental outcome at 2 years of age after general anaesthesia and awake-regional anaesthesia in infancy (GAS): an international multicentre, randomised …
Background Preclinical data suggest that general anaesthetics affect brain development.
There is mixed evidence from cohort studies that young children exposed to anaesthesia …
There is mixed evidence from cohort studies that young children exposed to anaesthesia …
[HTML][HTML] Morbidity and mortality after anaesthesia in early life: results of the European prospective multicentre observational study, neonate and children audit of …
Background Neonates and infants requiring anaesthesia are at risk of physiological
instability and complications, but triggers for peri-anaesthetic interventions and associations …
instability and complications, but triggers for peri-anaesthetic interventions and associations …
Effect of anesthesia on the developing brain: infant and fetus
DB Andropoulos - Fetal diagnosis and therapy, 2018 - karger.com
The potential for commonly used anesthetics and sedatives to cause neuroapoptosis and
other neurodegenerative changes in the developing mammalian brain has become evident …
other neurodegenerative changes in the developing mammalian brain has become evident …
Association of anesthesia and surgery during childhood with long-term academic performance
P Glatz, RH Sandin, NL Pedersen, AK Bonamy… - JAMA …, 2017 - jamanetwork.com
Importance The results of preclinical studies suggest that anesthetic drugs administered to
neonatal animals cause widespread neuronal apoptosis and later neurocognitive …
neonatal animals cause widespread neuronal apoptosis and later neurocognitive …
Association between exposure of young children to procedures requiring general anesthesia and learning and behavioral outcomes in a population-based birth …
D Hu, RP Flick, MJ Zaccariello, RC Colligan… - …, 2017 - pubs.asahq.org
Background Exposure of young animals to general anesthesia causes neurodegeneration
and lasting behavioral abnormalities; whether these findings translate to children remains …
and lasting behavioral abnormalities; whether these findings translate to children remains …