Patient and disease–specific induced pluripotent stem cells for discovery of personalized cardiovascular drugs and therapeutics
Human induced pluripotent stem cells (iPSCs) have emerged as an effective platform for
regenerative therapy, disease modeling, and drug discovery. iPSCs allow for the production …
regenerative therapy, disease modeling, and drug discovery. iPSCs allow for the production …
Use of human induced pluripotent stem cell–derived cardiomyocytes in preclinical cancer drug cardiotoxicity testing: a scientific statement from the American Heart …
It is now well recognized that many lifesaving oncology drugs may adversely affect the heart
and cardiovascular system, including causing irreversible cardiac injury that can result in …
and cardiovascular system, including causing irreversible cardiac injury that can result in …
Self-assembling human heart organoids for the modeling of cardiac development and congenital heart disease
YR Lewis-Israeli, AH Wasserman, MA Gabalski… - Nature …, 2021 - nature.com
Congenital heart defects constitute the most common human birth defect, however
understanding of how these disorders originate is limited by our ability to model the human …
understanding of how these disorders originate is limited by our ability to model the human …
The tumor-suppressive human circular RNA CircITCH sponges miR-330-5p to ameliorate doxorubicin-induced cardiotoxicity through upregulating SIRT6, survivin …
D Han, Y Wang, Y Wang, X Dai, T Zhou… - Circulation …, 2020 - Am Heart Assoc
Rationale: Doxorubicin is one of the most potent antitumor agents available; however, its
clinical use is restricted because it poses a risk of severe cardiotoxicity. Previous work has …
clinical use is restricted because it poses a risk of severe cardiotoxicity. Previous work has …
Metabolically driven maturation of human-induced-pluripotent-stem-cell-derived cardiac microtissues on microfluidic chips
The immature physiology of cardiomyocytes derived from human induced pluripotent stem
cells (hiPSCs) limits their utility for drug screening and disease modelling. Here we show …
cells (hiPSCs) limits their utility for drug screening and disease modelling. Here we show …
Metabolic aspects of anthracycline cardiotoxicity
M Russo, A Della Sala, CG Tocchetti… - … treatment options in …, 2021 - Springer
Opinion statement Heart failure (HF) is increasingly recognized as the major complication of
chemotherapy regimens. Despite the development of modern targeted therapies such as …
chemotherapy regimens. Despite the development of modern targeted therapies such as …
[HTML][HTML] Human engineered heart tissue models for disease modeling and drug discovery
The emergence of human induced pluripotent stem cells (hiPSCs) and efficient
differentiation of hiPSC-derived cardiomyocytes (hiPSC-CMs) induced from diseased …
differentiation of hiPSC-derived cardiomyocytes (hiPSC-CMs) induced from diseased …
Cardiac dysfunction in cancer patients: beyond direct cardiomyocyte damage of anticancer drugs: novel cardio-oncology insights from the joint 2019 meeting of the …
CG Tocchetti, P Ameri, RA de Boer… - Cardiovascular …, 2020 - academic.oup.com
In western countries, cardiovascular (CV) disease and cancer are the leading causes of
death in the ageing population. Recent epidemiological data suggest that cancer is more …
death in the ageing population. Recent epidemiological data suggest that cancer is more …
Functional dynamic genetic effects on gene regulation are specific to particular cell types and environmental conditions
AS Findley, A Monziani, AL Richards, K Rhodes… - Elife, 2021 - elifesciences.org
Genetic effects on gene expression and splicing can be modulated by cellular and
environmental factors; yet interactions between genotypes, cell type, and treatment have not …
environmental factors; yet interactions between genotypes, cell type, and treatment have not …
Modeling cardiac disease mechanisms using induced pluripotent stem cell-derived cardiomyocytes: progress, promises and challenges
Cardiovascular diseases (CVDs) are a class of disorders affecting the heart or blood
vessels. Despite progress in clinical research and therapy, CVDs still represent the leading …
vessels. Despite progress in clinical research and therapy, CVDs still represent the leading …