The immune-inflammatory response is associated with increased nitro-oxidative stress. The
aim of this mechanistic review is to examine:(a) the role of redox-sensitive transcription …

Natural killer (NK) cells are the predominant innate lymphocyte subsets that mediate anti-
tumor and anti-viral responses, and therefore possess promising clinical utilization. NK cells …

Background Combined immunodeficiencies are marked by inborn errors of T-cell immunity
in which the T cells that are present are quantitatively or functionally deficient. Impaired …

Sustained neuroinflammation mediated by resident microglia is recognized as a key
pathophysiological contributor to many neurodegenerative diseases, including Parkinson's …

Natural killer (NK) cells are the major lymphocyte subset of the innate immune system. Their
ability to mediate anti-tumor cytotoxicity and produce cytokines is well-established. However …

CARD11 functions as a key signaling scaffold that controls antigen-induced lymphocyte
activation during the adaptive immune response. Somatic mutations in CARD11 are …

Resolving how the early signaling events initiated by cell–cell interactions are transduced
into diverse functional outcomes necessitates correlated measurements at various stages …

Background Melanoma is the most fatal skin cancer displaying a high degree of molecular
heterogeneity. Phenotype switching is a mechanism that contributes to melanoma …

Natural killer (NK) cells are innate lymphocytes that play a major role in immunosurveillance
against tumor initiation and metastatic spread. The signals and checkpoints that regulate NK …

Preeclampsia is one of the three leading causes of maternal morbidity and mortality
worldwide. It afflicts 2–8% of pregnancies and is the most common cause of gestational …