Neuropathic pain caused by a lesion or disease of the somatosensory nervous system is a
common chronic pain condition with major impact on quality of life. Examples include …

Interactions between the immune and nervous systems are of central importance in
neuropathic pain, a common and debilitating form of chronic pain caused by a lesion or …

Sensory neurons of the dorsal root ganglion (DRG) are critical for maintaining tissue
homeostasis by sensing and initiating responses to stimuli. While most preclinical studies of …

The study of chronic pain continues to generate ever-increasing numbers of publications,
but safe and efficacious treatments for chronic pain remain elusive. Recognition of sex …

Sensitization of trigeminal ganglion neurons contributes to primary headache disorders such
as migraine, but the specific neuronal and non-neuronal trigeminal subtypes that are …

Neuropathic pain is a leading cause of high-impact pain, is often disabling and is poorly
managed by current therapeutics. Here we focused on a unique group of neuropathic pain …

Although sex dimorphism is increasingly recognized as an important factor in pain, female-
specific pain signaling is not well studied. Here we report that administration of IL-23 …

A neuroimmune crosstalk is involved in somatic and visceral pathological pain including
inflammatory and neuropathic components. Apart from microglia essential for spinal and …

Sciatic nerve crush injury triggers sterile inflammation within the distal nerve and axotomized
dorsal root ganglia (DRGs). Granulocytes and pro-inflammatory Ly6Chigh monocytes …

Peripheral nerve injury-induced neuropathic pain is a chronic and debilitating condition
characterized by mechanical hypersensitivity. We previously identified microglial activation …