Significance: Fluorescence lifetime imaging microscopy (FLIM) is a powerful technique to
distinguish the unique molecular environment of fluorophores. FLIM measures the time a …

Lipid droplets are cytoplasmic organelles that store neutral lipids and are critically important
for energy metabolism. Their function in energy storage is firmly established and …

Fluorescence lifetime imaging microscopy (FLIM) is used in diverse disciplines, including
biology, chemistry and biophysics, but its use has been limited by the complexity of the data …

The phasor approach to fluorescence lifetime imaging has become a common method to
analyze complicated fluorescence signals from biological samples. The appeal of the …

Significance: Optical imaging using the endogenous fluorescence of metabolic cofactors has
enabled nondestructive examination of dynamic changes in cell and tissue function both in …

Fluorescence lifetime imaging (FLI) provides unique quantitative information in biomedical
and molecular biology studies but relies on complex data-fitting techniques to derive the …

Bile acids are ligands for the nuclear hormone receptor farnesoid X receptor (FXR) and the
G protein–coupled receptor TGR5. We have shown that FXR and TGR5 have renoprotective …

The basis for region-specific neuronal toxicity in Huntington disease is unknown. Here, we
show that region-specific neuronal vulnerability is a substrate-driven response in astrocytes …

Retinal diseases are a rising concern as major causes of blindness in an aging society;
therapeutic options are limited, and the precise pathogenesis of these diseases remains …

Adipocytes are the main cell type in adipose tissue, which is a critical regulator of
metabolism, highly specialized in storing energy as fat. Adipocytes differentiate from …