Introduction Duchenne muscular dystrophy (DMD) is an X-linked recessive disorder caused
by mutations in the dystrophin (DMD) gene. Most patients die from respiratory failure or …

Skeletal muscle is an accessible adult stem-cell model in which differentiated myofibres are
maintained and repaired by a self-renewing stem-cell compartment. These resident stem …

Cell-penetrating peptides (CPPs), containing arginine (R), 6-aminohexanoic acid (X), and/or
β-alanine (B) conjugated to phosphorodiamidate morpholino oligomers (PMOs), enhance …

Histone deacetylases (HDACs) are enzymes that regulate the deacetylation of numerous
histone and non-histone proteins, thereby affecting a wide range of cellular processes …

Dystrophic muscle disease can occur at any age. Early-or childhood-onset muscular
dystrophies may be associated with profound loss of muscle function, affecting ambulation …

Key points• Strength loss induced by lengthening contractions is typically attributed to
damaged force‐bearing structures within skeletal muscle. Muscle lacking the structural …

Duchenne muscular dystrophy (DMD) is a devastating neuromuscular disease in which
weakness, increased susceptibility to muscle injury, and inadequate repair appear to …

Purpose Measuring the physical activity of adults with progressive muscle diseases is
important to inform clinical practice, for activity recommendations and for outcomes …

MicroRNAs (miRNAs) are small, non-coding RNA molecules that are mainly involved in
translational repression by binding to specific messenger RNAs. Recently, miRNAs have …

Duchenne muscular dystrophy (DMD) is a devastating neuromuscular disease in which
weakness, increased susceptibility to muscle injury, and inadequate repair underlie the …