Cellular senescence as a mechanism and target in chronic lung diseases

PJ Barnes, J Baker, LE Donnelly - American journal of respiratory …, 2019 - atsjournals.org
Cellular senescence is now considered an important driving mechanism for chronic lung
diseases, particularly chronic obstructive pulmonary disease (COPD) and idiopathic …

[HTML][HTML] Mechanisms contributing to the comorbidity of COPD and lung cancer

A Forder, R Zhuang, VGP Souza, LJ Brockley… - International Journal of …, 2023 - mdpi.com
Lung cancer and chronic obstructive pulmonary disease (COPD) often co-occur, and
individuals with COPD are at a higher risk of developing lung cancer. While the underlying …

[HTML][HTML] Recent advances in endothelial colony forming cells toward their use in clinical translation

KE Paschalaki, AM Randi - Frontiers in medicine, 2018 - frontiersin.org
The term “Endothelial progenitor cell”(EPC) has been used to describe multiple cell
populations that express endothelial surface makers and promote vascularisation. However …

[HTML][HTML] MicroRNAs as potential regulators of immune response networks in asthma and chronic obstructive pulmonary disease

JA Cañas, JM Rodrigo-Muñoz, B Sastre… - Frontiers in …, 2021 - frontiersin.org
Chronic respiratory diseases (CRDs) are an important factor of morbidity and mortality,
accounting for approximately 6% of total deaths worldwide. The main CRDs are asthma and …

Senotherapy: a new horizon for COPD therapy

JR Baker, LE Donnelly, PJ Barnes - Chest, 2020 - Elsevier
There is increasing evidence that COPD is a disease of accelerated lung aging, with the
accumulation of senescent cells that lose their ability to repair and secrete multiple …

[HTML][HTML] Chronic obstructive pulmonary disease: MicroRNAs and exosomes as new diagnostic and therapeutic biomarkers

J Salimian, H Mirzaei, A Moridikia… - Journal of Research …, 2018 - journals.lww.com
Chronic obstructive pulmonary disease (COPD) is known as a progressive lung disease and
the fourth leading cause of death worldwide. Despite valuable efforts, there is still no …

[HTML][HTML] The potential roles of exosomes in chronic obstructive pulmonary disease

N Wang, Q Wang, T Du, ANA Gabriel, X Wang… - Frontiers in …, 2021 - frontiersin.org
Currently, chronic obstructive pulmonary disease (COPD) is one of the most common
chronic lung diseases. Chronic obstructive pulmonary disease is characterized by …

[HTML][HTML] Characterization of pulmonary vascular remodeling and MicroRNA-126-targets in COPD-pulmonary hypertension

K Goel, N Egersdorf, A Gill, D Cao, SD Collum… - Respiratory …, 2022 - Springer
Background Despite causing increased morbidity and mortality, pulmonary hypertension
(PH) in chronic obstructive pulmonary disease (COPD) patients (COPD-PH) lacks treatment …

[HTML][HTML] MicroRNA miR-24-3p reduces DNA damage responses, apoptosis, and susceptibility to chronic obstructive pulmonary disease

J Nouws, F Wan, E Finnemore, W Roque, SJ Kim… - JCI insight, 2021 - ncbi.nlm.nih.gov
The pathogenesis of chronic obstructive pulmonary disease (COPD) involves aberrant
responses to cellular stress caused by chronic cigarette smoke (CS) exposure. However, not …

The roles of microRNAs in the pathogenesis of chronic obstructive pulmonary disease

X Huang, Z Zhu, X Guo, X Kong - International immunopharmacology, 2019 - Elsevier
Chronic obstructive pulmonary disease (COPD) is characterized by a progressive and
irreversible airflow obstruction, with an abnormal lung function. The etiology of COPD …